Engaging Home-monitored Assessment to Navigate Clinical Decision-making

NCT07399912 | Enrolling By Invitation

• 1 other identifier: 2024-4269-APP1
• Study Type: interventional
• Target: 116
• Locations: 1 country
• Sites: 1

Brief Summary

This study is testing a new app called ENHANCe, which is designed to help family doctors manage patients with high blood pressure using readings taken at home.

Conditions

Hypertension,Essential

Keywords

Hypertension; Home blood pressure; Primary Care; Clinical decision support system

Outcome Measures

Primary Outcomes (7)

• Response rate of participants

  Participants agreeable to participate in the study

  6 months

• Agreement with the CDSS recommendation among PCPs

  Proportion of PCPs who agree with the CDSS recommendation in the two groups

  6 months

• Withdrawal rate

  Proportion of participants who withdrew

  6 months

• Study completion rate

  Proportion of participants who completed the intervention

  6 months

• Adverse event rates

  Proportion of adverse events reported in the two groups

  6 months

• Consult duration

  Consult time in the groups

  6 months

• Ease of home blood pressure record assessment among PCPS

  Ease of home blood pressure record assessment among PCPS in the two arms

  6 months

Secondary Outcomes (2)

• Proportion of CDSS recommendation followed by the PCPS

  6 months

• Blood pressure control status

  6 months

Study Arms (2)

Hypertension management using the Clinical Decision Support System

EXPERIMENTAL

All patients will have access to online educational resources throughout the study. After recruitment, they will receive a nurse-led education on HBP monitoring. The research team will train all primary care physicians (PCPs) on managing patients with hypertension using HBP records. The PCPs in the intervention group will be briefed on how the ENHANCe app works, and its recommendations. The ENHANCe app will be installed on designated mobile phones, and research staff will analyse HBP records during visits, documenting the output for PCPs to use. Based on the app's recommendations, patients will consult with intervention group PCPs 2-3 times throughout the study, with the last follow-up at 6 months. PCPs will complete a consult checklist after each visit. FGDs will be conducted with PCPs at the end of the study. The interviews will be recorded and transcribed for analysis.

Device: ENHANCe app; Other: Teaching and training

Hypertension management as per usual care without a clinical decision support system

OTHER

All patients will have access to online educational resources throughout the study. After recruitment, they will receive a nurse-led education on HBP monitoring. The research team will train all primary care physicians (PCPs) on managing patients with hypertension using HBP records. Control group PCPs will manage patients using HBP records at their discretion, with a final follow-up scheduled at 6 months. PCPs will complete a consult checklist after each visit. Research staff will use the ENHANCe app to analyse BP diaries and document outcomes, but control group PCPs will not have access to the app or its results.

Other: Teaching and training; Other: Usual care

Interventions

ENHANCe app DEVICE

ENHANCe app is a prototype; it is a smartphone based clinical decision support (CDS) tool to manage patients with hypertension using their home blood pressure. The app will scan patients' home BP records from paper or mobile phone, and provide a recommendation to the doctor on how to manage their blood pressure. The patient will not need to use the device during the study period. However, the recommendation from the ENHANCe app will be available to the doctor to manage your blood pressure during the study period if the patient is in the intervention group.

Hypertension management using the Clinical Decision Support System

Teaching and training OTHER

All patients will have access to online educational resources throughout the study. After recruitment, they will receive a nurse-led education on HBP monitoring. The research team will train all primary care physicians (PCPs) on managing patients with hypertension using HBP records.

Hypertension management as per usual care without a clinical decision support system; Hypertension management using the Clinical Decision Support System

Usual care OTHER

Physicians manage patients using HBP records at their discretion

Hypertension management as per usual care without a clinical decision support system

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• For primary care physicians:
• PCPs aged 21 years and above.
• Involved in the clinical management of patients with hypertension in the past six months.
• For patients:
• Patients aged 21 years and above
• Documentation of hypertension diagnosis in EMR
• Owns an HBP monitoring device

You may not qualify if:

• Documentation of dementia diagnosis in EMR
• Audio or visual impairments
• Hypertensive urgency or emergency

Sponsors & Collaborators

• SingHealth Polyclinics: lead
• Nanyang Polytechnic: collaborator

Study Sites (1)

SingHealth Polyclinics

Singapore, Singapore, 150167, Singapore

Location

MeSH Terms

Conditions

Essential Hypertension; Hypertension

Interventions

Educational Status

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Socioeconomic Factors; Population Characteristics

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Patient Participants will be blinded to the group they are allocated to
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Parallel Cluster RCT

Study Record Dates

• First Submitted: December 28, 2025
• First Posted: February 10, 2026
• Study Start: October 1, 2025
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: February 10, 2026

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)