Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential Hypertension

NCT03778489 | Completed

• 1 other identifier: PANX-HYP
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,

Conditions

Hypertension,Essential

Keywords

Pannexin-1 channel

Outcome Measures

Primary Outcomes (1)

• Blood pressure

  Changes in systolic and diastolic blood pressure

  Before and after 8 weeks of training

Secondary Outcomes (12)

• Pannexin channel function assessed in vivo

  Before and after 8 weeks of training

• Pannexin channel distribution in skeletal muscle tissue

  Before and after 8 weeks of training

• Sympathetic activity

  Before and after 8 weeks of training

• Vascular function

  Before and after 8 weeks of training

• Mitochondrial function in endothelial cells

  Before and after 8 weeks of training

Study Arms (2)

Hypertensive

EXPERIMENTAL

Men and women in age-group 35-65 years Resting blood pressure of \>140/90 mmHg non or only anti-hypertensive medication

Other: Training

Control

ACTIVE COMPARATOR

Men and women in age-group 35-65 years Resting blood pressure of \<140/90 mmHg no medication

Other: Training

Interventions

Training OTHER

10 weeks of high intensity exercise training. 2-3 trainings per week of approx. 40 min.

Control; Hypertensive

Eligibility Criteria

• Age: 35 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Sedentary men and women age 35 - 65 years
• Resting blood pressure \>140/90 mmHg or Resting blood pressure \<140/90 mmHg
• Essential hypertension
• Non or exclusively antihypertensive medication

You may not qualify if:

• Hypertensive condition other than essential hypertension
• Other chronical diseases
• Smoking
• Excess alcohol intake or drug abuse

Sponsors & Collaborators

• University of Copenhagen: lead
• Lundbeck Foundation: collaborator
• Danish Council for Independent Research: collaborator

Study Sites (1)

University of Copenhagen

Copenhagen, 2100, Denmark

Location

Related Publications (1)

• Moller S, Hansen CC, Ehlers TS, Tamariz-Ellemann A, Tolborg SAR, Kurell ME, Perez-Gomez J, Patrzalek SS, Maulitz C, Hellsten Y, Gliemann L. Exercise Training Lowers Arterial Blood Pressure Independently of Pannexin 1 in Men with Essential Hypertension. Med Sci Sports Exerc. 2022 Sep 1;54(9):1417-1427. doi: 10.1249/MSS.0000000000002936. Epub 2022 Apr 12.

  PMID: 35420578 DERIVED

MeSH Terms

Conditions

Essential Hypertension

Condition Hierarchy (Ancestors)

Hypertension; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Randomized double blinded case-control interventional study

Study Record Dates

• First Submitted: December 6, 2018
• First Posted: December 19, 2018
• Study Start: February 19, 2019
• Primary Completion: November 1, 2022
• Study Completion: November 1, 2022
• Last Updated: November 2, 2022

Record last verified: 2022-11

Locations

DK (1)