Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index After Induction of General Anesthesia

NCT07399093 | Recruiting DMC

• 1 other identifier: FMASU MD08/2024
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to assess the accuracy, repeatability, and reproducibility of preoperative evaluation of Inferior Vena Cava (IVC) collapsibility index and caval aorta index for prediction of hypotension after induction of general anesthesia.

Conditions

Inferior Vena Cava; Collapsibility Index; Caval Aorta Index; Induction; General Anesthesia; Craniotomy

Outcome Measures

Primary Outcomes (1)

• Sensitivity of ultrasound guided Aorto-Caval index (IVC-AO)

  Sensitivity of ultrasound guided Aorto-Caval index (IVC-AO) to predict hypotension will be recorded.

  15 minutes post-induction of general anesthesia.

Secondary Outcomes (3)

• Specificity of ultrasound guided Aorto-Caval index (IVC-AO)

  15 minutes post-induction of general anesthesia.

• Sensitivity of inferior vena cava (IVC) collapsibility index

  15 minutes post-induction of general anesthesia.

• Specificity of inferior vena cava (IVC) collapsibility index

  15 minutes post-induction of general anesthesia.

Study Arms (1)

Study group

Patients scheduled for elective craniotomy surgeries before induction of general anesthesia.

Other: Inferior vena cava collapsibility index; Other: Caval Aorta Index

Interventions

Inferior vena cava collapsibility index OTHER

Inferior vena cava (IVC) collapsibility index (IVCCI) will be measured. The IVCCI is calculated using the following formula: IVCCI = (maximum IVC diameter - minimum IVC diameter) / maximum IVC diameter \* 100

Study group

Caval Aorta Index OTHER

The Inferior vena cava (IVC): Ao index will be derived by taking the ratio of the maximum IVC diameter during expiration and the maximal abdominal aortic diameter during systole. \- The caval aorta index (IVC/Ao) is calculated using the following formula: IVC/Ao index = IVC diameter / aortic diameter.

Study group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

This prospective cohort study will be conducted on 40 patients undergoing craniotomy surgeries at Ain Shams University Hospitals.

You may qualify if:

• Age from 18 to 40 years.
• Both sexes.
• Body Mass Index\< 40 kg/m².
• American Society of Anesthesiologists (ASA) physical status I, II.
• Fasted according to the ASA guidelines: 2 hours for clear fluids, 6 hours after light meal, 8 hours after a full meal with high calorie or fat content.
• Scheduled for elective craniotomy surgeries before induction of general anesthesia.

You may not qualify if:

• Current or recent pregnancy (within 3 months).
• Pre-existing cardiac disease or hypertension.
• On medications affecting blood pressure \[Beta-blockers (BBs) and calcium channel blockers (CCBs)\] .
• Refusing to undergo the study.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University Hospitals

Cairo, 11591, Egypt

RECRUITING

Central Study Contacts

Verina F Zaref, MSc

CONTACT

00201098858385; verina.fares@med.asu.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer of Anesthesia, Intensive Care and Pain Management, Ain Shams University, Cairo, Egypt

Study Record Dates

• First Submitted: July 24, 2025
• First Posted: February 10, 2026
• Study Start: January 14, 2024
• Primary Completion: March 1, 2026
• Study Completion: March 1, 2026
• Last Updated: February 10, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)