Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients

NCT07398365 | Recruiting

• 1 other identifier: 337967
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study will characterise the general psychiatric and general medical phenotypes of 100 adults, sequentially admitted to NHS General Adult Psychiatry (GAP) "mental health" inpatient wards, providing the first detailed information on morbidity in this patient population.

Conditions

Bipolar Affective Disorder; Depression Disorders; Schizophrenia Disorders; Personality Disorders

Keywords

General Adult Psychiatry; mental health; physical health; inpatients; schizophrenia; NHS; Bipolar affective disorder; depression; psychosis; treatment resistance; personality disorder; cardiometabolic disease; cancer; respiratory disease

Outcome Measures

Primary Outcomes (19)

• Rates of comorbid physical illnesses

  As per medical note review and physical examination - BMI

  At enrolment

• Psychiatric diagnosis

  ICD-11 codes

  At enrolment

• Severity of psychosis

  Brief Psychiatric Rating Scale (BPRS) score; 18 to 126, higher scores indicate more severe symptoms

  At enrolment

• Depression of severity

  Inventory of Depressive Symptomatology Self Report (IDS-SR); 0 to 84, higher scores indicate more severe symptoms

  At enrolment

• Severity of mania

  Young Mania Rating Scale score; 0 to 60, higher scores indicate more severe symptoms

  At enrolment

• Severity of anxiety

  General Anxiety Scale (GAD-7) score; 0 to 21, higher scores indicate more severe symptoms

  At enrolment

• Substance use

  Tobacco, Alcohol, Prescription medication, and other Substance use (TAPS) tool score; tobacco 0 to 3, alcohol 0 to 4, others 0 to 21, higher scores indicate more risky use

  At enrolment

• Mental Health Act status

  MHA detention status; informal or detained

  At enrolment

• Treatment resistance indicators

  Clozapine for psychosis, and ECT treatment and Massachusetts General Hospital Staging (MGH-S) score for depression. MGH-S uses the number of failed trials with the intensity/optimization of each trial to produce a score where \>3.5 defines treatment resistant depression

  At enrolment

• Rates of abnormal findings on physical examination

  When psychiatric patients are admitted to hospital, they are examined by a resident doctor, including inspection, auscultation, and palpation. Rates of abnormal findings on cardiovascular , respiratory, abdominal, and neurological examination will be noted..

  At enrolment

• Abnormal laboratory values

  When psychiatric patients are admitted to hospital, screening blood tests, including full blood count, urea and electrolytes (kidney), liver function tests, random glucose, cholesterol, triglycerides, and thyroid function tests.

  At enrolment

• Rates of comorbid physical illness

  As per medical note review and physical examination - blood pressure mmHg

  At enrolment

• Rates of comorbid physical illness

  As per medical note review and physical examination - cardiometabolic disease

  At enrolment

• Rates of comorbid physical illness

  As per medical note review and physical examination - neurological disease.

  At enrolment

• Rates of comorbid physical illness

  As per medical note review and physical examination - musculoskeletal disease

  At enrolment

• Rates of comorbid physical illness

  As per medical note review and physical examination - respiratory disease

  At enrolment

• Rates of comorbid physical illness

  As per medical note review and physical examination - renal disease

  At enrolment

• Rates of comorbid physical illness

  As per medical note review and physical examination - hepatic disease

  At enrolment

• Rates of comorbid physical illness

  As per medical note review and physical examination - haematological disease

  At enrolment

Study Arms (4)

Group 1 - Schizophrenia Group

* Schizophrenia - 6A20 * Schizoaffective disorder - 6A21 * Delusional disorder - 6A24 * Other primary psychotic disorders (psychosis NOS) - 6A2Z * Schizotypal disorder - 6A23

Other: Questionnaires, rating scales, & review of notes

Group 2 - Bipolar Group

* Bipolar type I disorder, current episode manic - 6A60 • without psychotic symptoms - 6A60.0 • with psychotic symptoms - 6A60.2 * Bipolar type II disorder, current episode depressed, with psychotic symptoms - 6A60.6

Other: Questionnaires, rating scales, & review of notes

Group 3 -Depression Group

* Recurrent depressive disorder, current severe episode without psychotic symptoms - 6A71.3 * Single episode depressive disorder, moderate with psychotic symptoms - 6A70.2 * Recurrent depressive disorder (not otherwise specified) - 6A71 * Mixed depressive and anxiety disorder - 6A73

Other: Questionnaires, rating scales, & review of notes

Group 4 - Personality Group

* Personality disorder - 6D10, 6D10.Z * Complex post-traumatic stress disorder - 6B41 * Substance use disorders - 6C4\* codes (e.g., 6C4G.1 alcohol, 6C45.6 sedative-hypnotic, 6C43.2 cannabis, 6C44.2 stimulants, 6C4Z unspecified)

Other: Questionnaires, rating scales, & review of notes

Interventions

Questionnaires, rating scales, & review of notes OTHER

Observational - questionnaires, rating scales, \& review of notes

Group 1 - Schizophrenia Group; Group 2 - Bipolar Group; Group 3 -Depression Group; Group 4 - Personality Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults (≥18 years) consecutively admitted to NHS GAP inpatient wards in Scotland.

You may qualify if:

• \- Adults aged between 18 and 65 years admitted to GAP wards during recruitment period

You may not qualify if:

• \- Admissions to non-GAP wards (e.g., forensic psychiatry, young people's units, perinatal, old age psychiatry, or general medical wards)

Sponsors & Collaborators

• NHS Lothian: collaborator
• University of Edinburgh: lead
• University of Dundee: collaborator

Study Sites (1)

St John's Hospital

Livingston, West Lothian, EH16 4TJ, United Kingdom

RECRUITING

MeSH Terms

Conditions

Bipolar Disorder; Schizophrenia; Personality Disorders; Psychological Well-Being; Depression; Psychotic Disorders; Neoplasms; Respiration Disorders

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mood Disorders; Mental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Personal Satisfaction; Behavior; Behavioral Symptoms; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Douglas Steele

  University of Dundee

  STUDY DIRECTOR

Central Study Contacts

David Hayward

CONTACT

01506 523000; david.hayward@nhslothian.scot.nhs.uk

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 24, 2025
• First Posted: February 9, 2026
• Study Start: April 3, 2024
• Primary Completion: May 30, 2026
• Study Completion (Estimated): August 8, 2026
• Last Updated: May 5, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Access Criteria: Anonymous data available to co-investigators - diagnosis (ICD-11 codes), severity ratings (BPRS, IDS-SR, YMRS, Hamilton scales), MHA detention status, treatment resistance indicators (e.g., clozapine, ECT treatment, MGH-S), comorbid physical diagnoses, abnormal findings on physical examination, abnormal laboratory values, cardiometabolic measures

Locations

GB (1)