A Pilot Study to Test the Efficacy of a Commercial Toothpaste (Cosmetic Product)

NCT07397312 | Recruiting

• 1 other identifier: CosTP-001
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 3

Brief Summary

This clinical multi-center, controlled, study will be carried out in volunteers with every 3- to 6-months professional tooth cleaning during their non-treatment period between 2 re-calls of a supportive periodontitis therapy regime. The efficacy of domestic oral hygiene by using a commercial dentifrice will be determined. Besides regularly used ingredients such as NaF and cleaning bodies the dentifrice contains a novel compound, which may be beneficial for the protection of an eubiotic oral microbiome. During the 3-month study period, participants will brush with their allocated study product twice daily.

Conditions

Periodontitis

Keywords

periodontitis; toothpaste

Outcome Measures

Primary Outcomes (1)

• Efficacy before and after 3 months of using newly developed microbiome-modulating toothpaste

  From enrollment to the end of treatment at 12 weeks.

Study Arms (1)

toothpaste

EXPERIMENTAL

Other: Toothpaste

Interventions

Toothpaste OTHER

brushing teeth with toothpaste twice a day for and refrain from mouth rinsing after spitting out

toothpaste

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Demonstrates understanding of the study procedures, restrictions and willingness to participate as evidenced by voluntary written informed consent and has received a signed and dated copy of the informed consent form.
• Good general health with no clinically significant and relevant abnormalities of medical history.
• Absence of any condition that would impact on the subject's safety or wellbeing or affect the individual's ability to understand and follow study procedures and requirements.
• At Screening (Visit 1):
• Participant with at least 16 natural, permanent teeth.
• A participant who gets regularly professional tooth cleaning in a frequence of once to twice yearly.
• Participant whose biofilm contains at least Porphyromonas gingivalis.

You may not qualify if:

• A participant who is an employee of the investigational site, either directly involved in the conduct of the study or a member of their immediate family; or an employee of the investigational site otherwise supervised by the investigator; or a sponsor's employee directly involved in the conduct of the study or a member of their immediate family.
• A participant who has participated in other studies (including non-medicinal studies) involving investigational product(s) within 30 days prior to study entry and/or during study participation.
• A participant with an acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator or medically qualified designee, would make the participant inappropriate for entry into this study.
• A participant who has any other clinical serious or unstable conditions (for example, cardiovascular diseases, diabetes, liver disorders, bleeding disorders, and kidney disorders) which could have affected study outcomes and/or participant safety.
• A participant who has a Plaque Control Record (PCR) \> 35 %.
• A participant who plans to get pregnant during the study or is already pregnant (pregnancy testing) or breastfeeding.
• A participant who is known or suspected of intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients.
• A participant who is unwilling or unable to comply with the lifestyle considerations.
• Participant who is a current smoker (more than 5 cigarettes per day).
• Participant who is using smokeless forms of tobacco (for example, chewing tobacco, gutkha, pan containing tobacco, nicotine-based e-cigarettes).
• A participant who is diagnosed with xerostomia or is taking any medication that is causing xerostomia.
• A participant who has a recent history (within the last year) of alcohol or other substance abuse.
• A participant who has a severe oral condition (for example, necrotizing gingivitis/periodontitis or oral or peri-oral ulceration) that could compromise study outcomes or the oral health of the participant/examiner if they participate in the study.
• A participant who has previously been enrolled in this study.
• A participant who is currently taking an anti-inflammatory or systemic medication (for example, immunosuppressants), which could affect plaque/gingival condition (for example, ibuprofen, aspirin, cyclosporin, phenytoin, calcium channel blockers) repeatedly for more than 3 consecutive days within study participation.

Sponsors & Collaborators

• Periotrap Pharmaceuticals GmbH: lead

Study Sites (3)

Dr. Hofmann

Bietigheim-Bissingen, 74321, Germany

NOT YET RECRUITING

Dr. T. Schütz

Borna, 04552, Germany

RECRUITING

Dr. G. Jungbauer

Straubing, 94315, Germany

RECRUITING

MeSH Terms

Conditions

Periodontitis

Interventions

Toothpastes

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dentifrices; Biomedical and Dental Materials; Manufactured Materials; Technology, Industry, and Agriculture

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 2, 2026
• First Posted: February 9, 2026
• Study Start: July 28, 2025
• Primary Completion: July 31, 2026
• Study Completion: July 31, 2026
• Last Updated: February 9, 2026

Record last verified: 2026-02

Locations

DE (3)