Tinder Fungus as an Adjunct to Non-surgical Periodontal Therapy for Periodontitis

NCT07482878 | Not Yet Recruiting

• 1 other identifier: 19113705
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this interventional clinical study is to learn if a Tinder fungus-based formulation -specifically a toothpaste and oral supplement powder-works as adjuncts to non-surgical periodontal therapy (NSPT) in patients with periodontitis. The main questions it aims to answer is:

• Does the Tinder fungus-based formulation as an adjunct to NSPT reduce bleeding on probing more than a commercially available toothpaste as an adjunct to NSPT? Researchers will compare tinder fungus toothpaste and oral powder as an adjunct to NSPT to a commercially available toothpaste as an adjunct to NSPT to see if the Tinder fungus-based formulation works as adjuncts to NSPT in patients with periodontitis. Participants will:
• Take tinder fungus toothpaste and oral powder or a commercially available toothpaste as an adjunct to NSPT twice daily for 30 consecutive days
• Visit the clinic at least twice including a visit before and after the intervention
• Keep a diary documenting their well-being and the number of times they used the toothpastes in the morning and evening.

Conditions

Periodontitis

Outcome Measures

Primary Outcomes (1)

• Bleeding on probing (BoP in %) change

  Bleeding on probing (BoP in %) changes from baseline (T0) to reevaluation (T1). BOP will be recorded as yes/no for each of 6 sites and reported as the percentage of affected sites per participant.

  changes from baseline (T0; 1 day before intervention starts) to reevaluation (T1; 5 weeks (±1 week) after intervention start)

Study Arms (2)

Tinder fungus-based formulation (toothpaste and oral supplement powder)

EXPERIMENTAL

Tinder fungus toothpaste plus oral supplement powder as adjuncts to non-surgical periodontal therapy (NSPT) in patients with periodontitis

Other: Tinder fungus-based formulation

commercially available toothpaste

ACTIVE COMPARATOR

Commercially available toothpaste as adjuncts to non-surgical periodontal therapy (NSPT) in patients with periodontitis

Other: Commercially available toothpaste

Interventions

Tinder fungus-based formulation OTHER

Participants will receive Tinder fungus (Fomes fomentarius)-based formulations including a toothpaste plus an oral supplement powder as adjuncts to non-surgical periodontal therapy (NSPT).

Tinder fungus-based formulation (toothpaste and oral supplement powder)

Commercially available toothpaste OTHER

A standard commercially available toothpaste administered as an adjunct to NSPT.

commercially available toothpaste

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients diagnosed with Stage III or IV periodontitis
• Patients who have not yet initiated periodontal therapy
• Patients who have at least 20 remaining teeth
• Patients who are willing to use an electric toothbrush
• Patients who are willing to use interdental brushes

You may not qualify if:

• Patients who have previously received treatment for periodontitis
• Patients who have already undergone or initiated periodontal therapy
• Patients with a known allergy or intolerance to any component of the toothpaste or the powder
• Patients who are already using a product that contains tinder fungus (Fomes fomentarius)

Sponsors & Collaborators

• Sigmund Freud PrivatUniversitat: lead

Study Sites (1)

Dental Clinic of the Sigmund Freud Private University

Vienna, State of Vienna, 1020, Austria

Location

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2026
• First Posted: March 19, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2028
• Last Updated: July 16, 2026

Record last verified: 2026-01

Locations

AU (1)