Improving Weight Loss in Healthy Adults With Overweight and Obesity: An Artificial Intelligence-assisted Dietary Prediction and Prevention System With Continuous Glucose Monitoring

NCT07395466 | Active Not Recruiting

• 1 other identifier: NUS-IRB-2023-597
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to examine the effectiveness of a novel dietary lapse prediction and prevention self-regulation app called the eating behaviour trigger-response inhibition program (eTRIP), and the addition of continuous glucose monitoring (CGM), on healthy eating and weight loss in people with overweight and obesity.

Conditions

Overweight , Obesity; Overweight or Obese Adults; Obesity; Overweight and/or Obesity

Outcome Measures

Primary Outcomes (5)

• Height

  Taken using a wall mounted measuring tape.

  At weeks 0, 10 and 24.

• Weight

  Taken using InBody 120

  At weeks 0, 10 and 24.

• Waist Circumference

  Taken using a measuring tape.

  At weeks 0, 10 and 24.

• BMI

  Taken using InBody 120

  At weeks 0, 10 and 24.

• Self regulation of Eating Behaviour Questionnaire (SREBQ)

  The Self-Regulation of Eating Behaviour Questionnaire (SREBQ) is a validated self-administered instrument used to assess individuals' self-regulation in relation to eating behavior. It evaluates the extent to which individuals monitor, control, and regulate their eating behaviors in everyday contexts. Higher scores indicate greater self-regulation of eating behavior.

  At weeks 0, 10 and 24.

Secondary Outcomes (12)

• Patient Health Questionnaire-2 (PHQ-2)

  At weeks 0, 10 and 24.

• Euro Quality of life 5 Dimensions-5 Levels (EQ-5D-5L)

  At weeks 0, 10 and 24.

• Generalized Anxiety Disorder 2-item (GAD-2)

  At weeks 0, 10 and 24.

• Percentage Body Fat

  At weeks 0, 10 and 24.

• Body Fat Mass

  At weeks 0, 10 and 24.

Study Arms (3)

eTRIP smartphone application

EXPERIMENTAL

Intervention group 1 involves using the eating behaviour trigger-response inhibition program(eTRIP) smartphone application for 10 weeks, where participants will need to take pictures of their food items as part of their food logging and may also engage with app-based activities to build self-regulatory skills in sticking to their weight loss plans. Additionally, participants will also apply a continuous glucose monitoring (CGM) sensor on their arm and taught how to scan the CGM sensor so that they can monitor their glucose levels for the first 10 days.

Behavioral: eTRIP

FatSecret smartphone application

SHAM COMPARATOR

Intervention group 2 involves using the FatSecret smartphone application for participants to monitor their calorie intake, without any continuous glucose monitoring.

Other: FatSecret

Control

NO INTERVENTION

Control group will not receive any smartphone application or continuous glucose monitoring.

Interventions

eTRIP BEHAVIORAL

Intervention group 1 involves using the eating behaviour trigger-response inhibition program(eTRIP) smartphone application for 10 weeks, where participants will need to take pictures of their food items as part of their food logging and may also engage with app-based activities to build self-regulatory skills in sticking to their weight loss plans. Additionally, participants will also apply a continuous glucose monitoring (CGM) sensor on their arm and taught how to scan the CGM sensor so that they can monitor their glucose levels for the first 10 days.

eTRIP smartphone application

FatSecret OTHER

Intervention group 2 involves using the FatSecret smartphone application for participants to monitor their calorie intake, without any continuous glucose monitoring.

FatSecret smartphone application

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• are 21-65 years old
• have BMI ≥23 kg/m2
• can comprehend the English language
• uses a smartphone that can download apps
• are willing to perform continuous glucose monitoring (CGM) using the Dexcom continuous glucose monitoring system
• willing to travel to the National University of Singapore (NUS)
• able to provide informed consent

You may not qualify if:

• are using/intend to use other apps for weight loss;
• are pregnant or lactating (as it would affect weight change and caloric needs)
• are diagnosed severe mental disorders (e.g. major depressive disorder and schizophrenia)
• are on prescribed meal replacements or pharmacotherapy
• have serious medical conditions
• are scheduled for any kind of surgery within the next 6 months

Sponsors & Collaborators

• National University Health System, Singapore: lead

Study Sites (1)

National University of Singapore

Singapore, 117597, Singapore

Location

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 24, 2025
• First Posted: February 9, 2026
• Study Start: January 22, 2025
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: February 9, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)