Thymoquinone Around Immediate Implant

NCT07391384 | Not Yet Recruiting DMC

• 2 other identifiers: Thymoquinon+ immediate implantcommittee 1238
• Study Type: interventional
• Target: 44
• Locations: 0 countries
• Sites: N/A

Brief Summary

use of Thymoquinone hydrogel with bone graft in comparison to bone graft only around immediate implant-this hydrogel fill the jumping zone in comparison to using hydrogel bone graft only to increase primary stability and enhance osseointegration

Conditions

Immediate Dental Implant Placement; Jumping Gap; Primary Stability of the Implants

Keywords

immediate implant; thymoquinone; hydrogel; bone graft

Outcome Measures

Primary Outcomes (1)

• primary stability

  Evaluate the primary stability by osstell pre- and post-3-month during abutment placement, this meaure from 1-99 ISQ

  0, 3 months

Secondary Outcomes (2)

• secondary outcomes

  baseline, 3 months, and 6 months

• secondary outcome

  3 months and 6 months

Study Arms (2)

surgical implants will inserted immediately after teeth extraction with xenograft.

PLACEBO COMPARATOR

immediat implant placement with bone graft hydrogel

Procedure: group 1 xenograft hydrogel

study group

ACTIVE COMPARATOR

surgical placement of 22 implants will inserted immediately after teeth extraction, combined xenograft and TQ gel.

Procedure: immediat implant placement wit TQ and bone graft hydrogel placement around implant

Interventions

group 1 xenograft hydrogel PROCEDURE

22 implants will inserted immediately after teeth extraction with xenograft.

Also known as: control group

surgical implants will inserted immediately after teeth extraction with xenograft.

immediat implant placement wit TQ and bone graft hydrogel placement around implant PROCEDURE

22 implants will inserted immediately after teeth extraction, combined xenograft and TQ gel.

study group

Eligibility Criteria

• Age: 20 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients ages more than 18 years old, Participants were chosen according to specific eligibility criteria, requiring them to be healthy individuals classified as ASA I by the American Society of Anesthesiologists.
• Patients requiring extraction of posterior teeth with consequent immediate implant placement.
• Indications for extraction included: non restorable teeth (posterior teeth), untreatable caries, endodontic failures, remaining roots, vertical fracture of the roots.
• Natural teeth adjacent to the tooth to be extracted will required to have complete occlusal surfaces and be free from infections..
• \. Patients will selected with a thick soft tissue phenotype and a minimum keratinized tissue width (KTW) of 2 mm.

You may not qualify if:

• Pathologies or drugs that alter tissue integration with dental implants. 2- Head and neck radiation therapy. 3- Renal disease, bleeding disorders and anticoagulant therapy. 4- Pregnant females. 5- Patients with severe para-functional habits and unfavorable occlusion 6- Smokers. 7- Malaligned teeth and teeth with acute periapical pathosis.

Sponsors & Collaborators

• shaimaa hamdy: lead

MeSH Terms

Interventions

Control Groups

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Officials

• aya kamal

  lecturer of periodontology Minia University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

shaimaa Hamdy, lecturer of Periodontology

CONTACT

+201030576405; shimaa.3m.sh@gmail.com

Turky, doctor

CONTACT

shimaa.3m.sh@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: All participants, investigators, surgeons, and outcomes investigator are masked
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: lecturer of periodontology

Model Details: The study will include 44 immediate implants replacing non-restorable posterior teeth. The patients were randomly assigned in equal numbers to two groups using http://www.randomizer.org Group I (Control): 22 implants will be inserted immediately after tooth extraction with xenograft. Group II (Study): 22 implants will be inserted immediately after tooth extraction, combined with xenograft and TQ gel.

Study Record Dates

• First Submitted: January 21, 2026
• First Posted: February 5, 2026
• Study Start: January 21, 2026
• Primary Completion: February 10, 2026
• Study Completion: April 11, 2026
• Last Updated: February 5, 2026

Record last verified: 2026-01