Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic

NCT07389551 | Completed

• 1 other identifier: Dr-Usman-QAMC
• Study Type: interventional
• Target: 142
• Locations: 1 country
• Sites: 1

Brief Summary

There are extensive gaps in the local data considering pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia. Therefore, the current study was planned with the objective of comparing pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia.

Conditions

Orthopedic Surgery

Outcome Measures

Primary Outcomes (2)

• Pain severity

  The severity of pain was analyzed on the visual analogue scale (VAS), with a lower score labelling the effectiveness of the treatment.

  24 hours

• Analgesia duration

  The duration of analgesia was measured from awakening to the need of rescue analgesia, when a pain score was more than 3 on VAS.

  24 hours

Study Arms (2)

Group-G

EXPERIMENTAL

Patients were given a single oral dose of gabapentin 300 mg, with 30 ml of water, one hour prior to administration of spinal anesthesia.

Drug: Gabapentin

Group-P

EXPERIMENTAL

Patients received pregabalin 150 mg as a single oral dose, with 30 ml of water, one hour prior to administration of spinal anesthesia

Drug: Pregabalin

Interventions

Gabapentin DRUG

Patients were given a single oral dose of gabapentin 300 mg, with 30 ml of water, one hour prior to administration of spinal anesthesia.

Group-G

Pregabalin DRUG

Patients received pregabalin 150 mg as a single oral dose, with 30 ml of water, one hour prior to administration of spinal anesthesia.

Group-P

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Either gender
• Aged 20-60 years
• Undergoing lower limb orthopedic surgeries under spinal anesthesia

You may not qualify if:

• Patients with a previous history of spine interventions, including surgery or injections (transforaminal, epidural, or facetal) for pain relief
• Patients under any sort of pain modulation therapy, like transcutaneous electrical nerve stimulation
• Patients had a long-term history of any analgesia use
• Those with psychiatric disorders, alcohol/drug dependence, hepatic, renal, cardiac, or pulmonary abnormalities,
• With a history of allergies to gabapentinoids

Sponsors & Collaborators

• Muhammad Aamir Latif: lead

Study Sites (1)

Victoria Hospital/Qaid-e-Azam Medical College

Bahawalpur, Punjab Province, 63100, Pakistan

Location

MeSH Terms

Interventions

Gabapentin; Pregabalin

Intervention Hierarchy (Ancestors)

Amines; Organic Chemicals; gamma-Aminobutyric Acid; Aminobutyrates; Butyrates; Acids, Acyclic; Carboxylic Acids; Cyclohexanecarboxylic Acids; Acids, Carbocyclic; Cyclohexanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Muhammad Usman

  Bahawal Victoria Hospital/Quid-e-Azam Medical College, Bahawalpur

  PRINCIPAL INVESTIGATOR

• Ambreen Khan, FCPS

  Bahawal Victoria Hospital/Quid-e-Azam Medical College, Bahawalpur

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research Consultant

Study Record Dates

• First Submitted: January 29, 2026
• First Posted: February 5, 2026
• Study Start: July 1, 2025
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: February 5, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)