Screening in Relatives With Elevated Risk for Unruptured Intracranial Aneurysms

NCT07387575 | Enrolling By Invitation DMC

• 1 other identifier: 00-18
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to screen first-degree relatives of patients with aneurysmal subarachnoid hemorrhage using magnetic resonance angiography to detect unruptured intracranial aneurysms. This study aims to identify individuals who are at increased risk and determine the effect of environmental factors for development of unruptured intracranial aneurysms.

Conditions

Intracranial Aneurysms; Subarachnoid Hemorrhage, Aneurysmal

Keywords

Stroke; Intracranial Aneurysm; Brain Aneurysm; Familial Intracranial Aneurysm; Aneurysmal Subarachnoid Hemorrhage

Outcome Measures

Primary Outcomes (1)

• Detection of unruptured intracranial aneurysms by magnetic resonance angiography (MRA).

  The proportion of screened first-degree relatives (aged ≥30) who are found to have one or more UIAs.

  At the time of screening (single MRA examination)

Secondary Outcomes (4)

• Correlation of aneurysm presence with risk factors

  At the time of screening

• Aneurysm size and location

  At the time of screening

• Prevalence of multiple aneurysms

  At the time of screening

• Assessment of anatomical variations of cerebral arteries

  At the time of screening

Study Arms (1)

Study Group

150 individuals that are first-degree relatives of affected patients admitted to study center for aneurysmal stroke and 150 individuals with sporadic UIAs

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will enroll first-degree relatives of patients with aneurysmal stroke who are aged 30 years or older, current smokers or have hypertension and individuals with sporadic UIAs and no past family history of aneurysmal stroke or UIAs. Participants must be able to undergo magnetic resonance angiography (MRA) and provide informed consent. Individuals with a prior intracranial aneurysm rupture, contraindications to MRI/MRA, pregnancy, or history of polycystic kidney disease, Marfan's Syndrome, Ehlers Danlos Syndrome, or fibromuscular dysplasia.

You may qualify if:

• First-degree relatives (parents, siblings, or children) of patients diagnosed with aneurysmal subarachnoid hemorrhage (aSAH);
• Age ≥ 30 years at the time of enrollment, and current cigarette smokers or diagnosed with hypertension (either treated or untreated);
• Able and willing to undergo magnetic resonance angiography (MRA);
• \. Able to provide written informed consent; 6. Sporadic aneurysm subjects must have a confirmed UIAs

You may not qualify if:

• History of intracranial aneurysm rupture or prior subarachnoid hemorrhage;
• Contraindications to MRI/MRA (e.g., pacemaker, metallic implants, severe claustrophobia) or pregnancy (due to MRI safety considerations);
• A history of polycystic kidney disease, Marfan's Syndrome, Ehlers Danlos Syndrome, or fibromuscular dysplasia;
• Unable or unwilling to provide informed consent;
• Participation in another interventional study that could interfere with outcomes.

Sponsors & Collaborators

• University of Novi Sad: lead
• Clinical Center of Vojvodina: collaborator

Study Sites (1)

University Clinical Center of Vojvodina

Novi Sad, Vojvodina, 21137, Serbia

Location

MeSH Terms

Conditions

Intracranial Aneurysm; Subarachnoid Hemorrhage; Stroke

Condition Hierarchy (Ancestors)

Intracranial Arterial Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Intracranial Hemorrhages; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Nebojsa M Lasica, M.D.

  University of Novi Sad

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: January 27, 2026
• First Posted: February 4, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): January 31, 2027
• Study Completion (Estimated): January 31, 2027
• Last Updated: February 4, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)