The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma

NCT07386431 | Not Yet Recruiting

• 1 other identifier: 20250256
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma. The study will include patients for whom surgical treatment of bowel endometriosis is clinically indicated. This research would represent a significant advancement in evaluating the necessity of surgical intervention in asymptomatic patients or those with mild symptoms. Furthermore, it would provide a broader insight into the systemic impact of endometriosis on other organ systems, ultimately improving risk assessment and preventive measures.

Conditions

Endometriosis; Deep Endometriosis; Bowel Endometriosis; Colorectal Carcinoma; Colon Resection; Endometriosis Pelvic; Endometriosis Rectum; Carcinogenesis; Genetic Change; Infertility

Outcome Measures

Primary Outcomes (1)

• Comparison of gene expression in healthy and with endometriosis affected bowel.

  3 years

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: Endometriosis is a disease that most commonly affects women.
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Female patients aged 18 and over, treated at the Department of Reproduction for diagnosed deep endometriosis, including bowel endometriosis, for whom surgical treatment is indicated.

You may qualify if:

• Female patients aged 18 and over, treated at the Department of Reproduction for diagnosed deep endometriosis, including bowel endometriosis, for whom surgical treatment is indicated.

You may not qualify if:

• Patients with known inflammatory bowel disease (IBD), patients with a personal history of gynecological or gastrointestinal malignancy

Sponsors & Collaborators

• University Medical Centre Ljubljana: lead

Biospecimen

Retention: SAMPLES WITH DNA

Biopsy of the bowel with endometriotic nodule and healthy part of bowel

MeSH Terms

Conditions

Endometriosis; Colorectal Neoplasms; Carcinogenesis; Infertility

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Neoplastic Processes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Rok Struna, MD

CONTACT

+38631441111; rok.struna@kclj.si

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 26, 2026
• First Posted: February 4, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): October 1, 2028
• Study Completion (Estimated): May 1, 2029
• Last Updated: February 6, 2026

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share