NCT07383337

Brief Summary

The human olfactory system plays a crucial role in sensory perception, influencing emotional states, memory, and interpersonal interactions(1). Fragrance durability and intensity are critical factors in the evaluation of perfumes and other scented products. The ability of fragrance formulations to maintain consistent scent intensity over time is a major contributor to a product's overall efficacy and consumer satisfaction, Primary Aim To compare the perceived strength of a topical fragrance delivered via SpECs across a period of 8 hours using subjective ratings by participants and an independent examiner. Objectives

  1. 1.To investigate whether the encapsulated fragrance intensity, as perceived by participants, decreases less over time compared with fragrance alone, after application to the skin.
  2. 2.To investigate whether the encapsulated fragrance intensity, as perceived by an independent examiner, decreases less over time compared with fragrance alone, after application to the skin.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 26, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

February 3, 2026

Completed
12 days until next milestone

Study Start

First participant enrolled

February 15, 2026

Completed
14 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2026

Completed
Last Updated

February 5, 2026

Status Verified

February 1, 2026

Enrollment Period

14 days

First QC Date

January 26, 2026

Last Update Submit

February 3, 2026

Conditions

Perception, Self

Keywords

fragranceSpECsOlfactory

Outcome Measures

Primary Outcomes (1)

  • Sustained olfactory perception over time.

    The study will determine whether fragrance-loaded SpECs provides a sustained olfactory perception over time.

    6 hour period- 4 timepoints

Secondary Outcomes (2)

  • Impact of SpECs concentration on fragrance

    6 hour period- 4 timepoints

  • alignment between participant's and independent examiner's ratings

    6 hour period- 4 timepoints

Study Arms (2)

Group A: Fragrance loaded with a concentration of SpECs grains.

EXPERIMENTAL

Fragrance delivery system: SpECs loaded with fragrance (50mg/ml perfume)

Other: Fragrance

Group B: Fragrance loaded without SpECs grains

ACTIVE COMPARATOR

fragrance without SpECs

Other: Fragrance

Interventions

FragranceOTHER

this intervention involves the controlled use of specific fragrance with and withouth SpECs grains

Group A: Fragrance loaded with a concentration of SpECs grains.Group B: Fragrance loaded without SpECs grains

Eligibility Criteria

Age18 Years - 45 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsParticipation is limited to females, as the intervention focuses on factors specifically related to women's perception of fragrance.
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Females aged between 18 and 45 years.
  • No history of olfactory impairment, allergies to pollen or fragrances, or skin conditions.

You may not qualify if:

  • Current use of medications that affect olfactory function (e.g., antihistamines).
  • Pregnancy or breastfeeding.
  • Any active upper respiratory tract infection within 2 weeks of the clinical trial
  • Any known skin allergy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (3)

  • Herz RS. The Role of Odor-Evoked Memory in Psychological and Physiological Health. Brain Sci. 2016 Jul 19;6(3):22. doi: 10.3390/brainsci6030022.

    PMID: 27447673BACKGROUND

  • Diego-Taboada A , Maillet L , Banoub JH , Lorch M , Rigby AS , Boa AN , Atkin SL , Mackenzie G . Protein free microcapsules obtained from plant spores as a model for drug delivery: ibuprofen encapsulation, release and taste masking. J Mater Chem B. 2013 Feb 7;1(5):707-713. doi: 10.1039/c2tb00228k. Epub 2012 Nov 27.

    PMID: 32260776BACKGROUND

  • Wakil A, Mackenzie G, Diego-Taboada A, Bell JG, Atkin SL. Enhanced bioavailability of eicosapentaenoic acid from fish oil after encapsulation within plant spore exines as microcapsules. Lipids. 2010 Jul;45(7):645-9. doi: 10.1007/s11745-010-3427-y. Epub 2010 May 22.

    PMID: 20495964BACKGROUND

MeSH Terms

Conditions

Anosmia

Interventions

Odorants

Condition Hierarchy (Ancestors)

Olfaction DisordersSensation DisordersNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

EnvironmentEcological and Environmental PhenomenaBiological PhenomenaEnvironment and Public Health

Study Officials

  • Mariam Murad

    Royal College of Surgeons, Ireland

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Mariam Murad

CONTACT

16660087mmurad@rcsi.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, CARE PROVIDER
Masking Details
Pilot randomized, double-blind crossover trial
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 26, 2026

First Posted

February 3, 2026

Study Start

February 15, 2026

Primary Completion

March 1, 2026

Study Completion

March 1, 2026

Last Updated

February 5, 2026

Record last verified: 2026-02