NCT07382765

Brief Summary

The goal of this study is to assess the effectiveness of the text-based ITG intervention to promote behaviors associated with HIV prevention amongst 18-22 year-olds in Uganda. The main questions the study aims to answer are:

  1. 1.In a twelve-month period, does the intervention increase HIV testing and use of condoms?
  2. 2.How is effectiveness different for populations based on education, sex, and location (urban/rural)? Researchers will compare the control group, with no intervention, and the three combinations of the three intervention components: quiz questions, milestone badges, and access to on-demand advice.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
750

participants targeted

Target at P75+ for not_applicable hiv

Timeline
23mo left

Started Mar 2026

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress13%
Mar 2026Jun 2028

First Submitted

Initial submission to the registry

January 27, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 3, 2026

Completed
26 days until next milestone

Study Start

First participant enrolled

March 1, 2026

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2028

Last Updated

February 3, 2026

Status Verified

December 1, 2025

Enrollment Period

2.3 years

First QC Date

January 27, 2026

Last Update Submit

January 27, 2026

Conditions

HIV

Outcome Measures

Primary Outcomes (2)

  • HIV testing

    Binary variable. Was the participant tested for HIV during the study?

    12 months

  • Condom-protected sex acts

    Self-reported count of condom-protected sex acts during study

    12 months

Study Arms (5)

Control

NO INTERVENTION

Quiz and badge

EXPERIMENTAL

Receives quiz and badge interactive elements

Other: Level up quizzesOther: BadgesOther: Content

Bagde and buddy

EXPERIMENTAL

Badges and advice are the only interactive elements

Other: BadgesOther: On-demand adviceOther: Content

Quiz and buddy

EXPERIMENTAL

Advice buddy and level up quizzes are only interactive parts of intervention

Other: Level up quizzesOther: On-demand adviceOther: Content

No interactive elements

EXPERIMENTAL

Receives educational content with no interactive elements

Other: Content

Interventions

Level up quizzesOTHER

Participant is given weekly quiz questions on that week's texted content

Quiz and badgeQuiz and buddy
BadgesOTHER

Participants can earn badges by performing activities encouraged by program

Bagde and buddyQuiz and badge
On-demand adviceOTHER

Participants have access to ITGenie/Text Buddy, which responds to keywords with preset messages

Bagde and buddyQuiz and buddy
ContentOTHER

Texted information about HIV prevention

Bagde and buddyNo interactive elementsQuiz and badgeQuiz and buddy

Eligibility Criteria

Age18 Years - 22 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Live in Uganda
  • Age 18 to 22
  • Have exclusive ownership of a cell phone
  • Have used text messaging for at least 6 months
  • Able to read English, Luganda, Runyakitara, or Luo

You may not qualify if:

  • Not participated in preliminary R34 study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Internet Solutions for Kids Uganda

Mbarara, Uganda

Location

Related Publications (4)

  • Collins LM, Kugler KC, Gwadz MV. Optimization of Multicomponent Behavioral and Biobehavioral Interventions for the Prevention and Treatment of HIV/AIDS. AIDS Behav. 2016 Jan;20 Suppl 1(0 1):S197-214. doi: 10.1007/s10461-015-1145-4.

    PMID: 26238037BACKGROUND

  • Ybarra ML, Agaba E, Nyemara N. A Pilot RCT Evaluating InThistoGether, an mHealth HIV Prevention Program for Ugandan Youth. AIDS Behav. 2021 Oct;25(10):3437-3448. doi: 10.1007/s10461-021-03237-5. Epub 2021 May 7.

    PMID: 33963477BACKGROUND

  • Matovu J, Wanynze R, Kasozi D. Assessment of the implementation processes and outcomes of the HIV assisted partner notification program in Uganda. Kampala: Makerere University School of Public Health. Published online July 2021.

    BACKGROUND

  • Bogart LM, Musoke W, Mukama CS, Allupo S, Klein DJ, Sejjemba A, Mwima S, Kadama H, Mulebeke R, Pandey R, Wagner Z, Mukasa B, Wanyenze RK. Enhanced Oral Pre-exposure Prophylaxis (PrEP) Implementation for Ugandan Fisherfolk: Pilot Intervention Outcomes. AIDS Behav. 2024 Oct;28(10):3512-3524. doi: 10.1007/s10461-024-04432-w. Epub 2024 Jul 19.

    PMID: 39028385BACKGROUND

MeSH Terms

Interventions

Film Dosimetry

Intervention Hierarchy (Ancestors)

Radiation MonitoringRadiometryInvestigative TechniquesRadiologic HealthPublic HealthEnvironment and Public Health

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 27, 2026

First Posted

February 3, 2026

Study Start

March 1, 2026

Primary Completion (Estimated)

June 1, 2028

Study Completion (Estimated)

June 1, 2028

Last Updated

February 3, 2026

Record last verified: 2025-12

Locations

UG(1)