Determinants of Medication Non-Adherence Among Patients With Chronic Diseases in Egyptian Community Pharmacies

NCT07375550 | Completed

• 1 other identifier: 3
• Study Type: observational
• Target: 261
• Locations: 1 country
• Sites: 1

Brief Summary

Medication non-adherence among patients with chronic diseases is a major public health concern and is associated with poor disease control, increased complications, and higher healthcare costs. Community pharmacists play an important role in supporting patients' medication use through counseling and education; however, the determinants of medication non-adherence among patients attending community pharmacies in Egypt are not well characterized. This multicenter, cross-sectional study aims to assess the prevalence of medication non-adherence and identify factors associated with non-adherence among adult Egyptian patients with chronic diseases attending community pharmacy settings. Medication adherence will be evaluated using the Adherence in Chronic Diseases Scale (ACDS), along with sociodemographic, clinical, and medication-related factors. The findings are expected to provide evidence to inform strategies for improving medication adherence and optimizing chronic disease management in community pharmacy practice in Egypt.

Conditions

Chronic Disease

Keywords

Chronic Disease; Egypt; Community pharmacy; Medication Adherence

Outcome Measures

Primary Outcomes (1)

• Prevalence of Medication Non-Adherence Among Patients with Chronic Diseases

  Medication non-adherence will be assessed using the Adherence in Chronic Diseases Scale (ACDS), a validated questionnaire designed to evaluate patients' adherence behaviors toward prescribed medications for chronic conditions. The outcome will be expressed as the proportion of participants classified as non-adherent and adherent based on ACDS scoring, and analyzed in relation to sociodemographic and clinical factors.

  Through study completion, an average of 1 month (cross-sectional assessment)

Secondary Outcomes (1)

• Determinants and Predictors of Medication Non-Adherence in Patients with Chronic Diseases

  Through study completion, an average of 1 month (cross-sectional assessment)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients aged 18 to 80 years who have been diagnosed with at least one chronic disease and are receiving long-term pharmacological treatment. Participants will be recruited from community pharmacy settings across multiple Egyptian cities Eligible patients are those attending participating community pharmacies during the study period and who are capable of understanding the study procedures and providing written informed consent. The study population reflects a real-world sample of patients managing chronic conditions in community pharmacy practice in Egypt.

You may qualify if:

• Adults aged 18 to 80 years.
• Diagnosed with at least one chronic disease requiring long-term pharmacological treatment.
• Currently receiving at least one prescribed medication for a chronic condition.
• Attending a participating community pharmacy during the study period.
• Able and willing to provide written informed consent.

You may not qualify if:

• Patients with cognitive impairment or mental conditions that limit their ability to understand the study procedures or complete the questionnaire.
• Patients who refuse or are unable to provide written informed consent.
• Patients who are acutely ill and unable to participate at the time of data collection.

Sponsors & Collaborators

• Egyptian Chinese University: lead

Study Sites (1)

Community pharmacies

Cairo, Egypt

Location

MeSH Terms

Conditions

Chronic Disease; Medication Adherence

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator: Assisstant Professor of Pharmacy Practice Faculty of pharmacy and Drug Technology

Study Record Dates

• First Submitted: December 30, 2025
• First Posted: January 29, 2026
• Study Start: January 1, 2026
• Primary Completion: March 1, 2026
• Study Completion: March 1, 2026
• Last Updated: April 21, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)