NCT07375459

Brief Summary

The goal of this pilot trial is to evaluate the feasibility of a mobile-assisted brief intervention for smoking cessation in community-based individuals in Singapore. Specific aims include:

  1. 1.To assess how many eligible individuals accept the invitation to participate in the trial
  2. 2.To assess the retention of the participants through 6 months after treatment initiation
  3. 3.To assess the acceptability of the intervention in terms of participants' engagement and ratings
  4. 4.To examine the intervention effect on abstinence outcomes

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
10mo left

Started Feb 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress31%
Feb 2026Mar 2027

First Submitted

Initial submission to the registry

January 22, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

January 29, 2026

Completed
6 days until next milestone

Study Start

First participant enrolled

February 4, 2026

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2027

Last Updated

April 9, 2026

Status Verified

April 1, 2026

Enrollment Period

11 months

First QC Date

January 22, 2026

Last Update Submit

April 8, 2026

Conditions

Smoking &Amp; Tobacco Cessation

Keywords

mHealthWhatsAppsmoking cessationchat-based interventionSingapore

Outcome Measures

Primary Outcomes (3)

  • Biochemically validated smoking abstinence rate

    Defined as an exhaled carbon monoxide level of \<5 parts per million or a negative salivary cotinine test (cut off 30ng/mL)

    6 months

  • Recruitment rate

    Number of participants divided by the number of eligible subjects

    6 months

  • Retention rate

    Number of participants completed the follow-up divided by the number of participants

    6 months

Secondary Outcomes (8)

  • Self-reported 7-day point-prevalence smoking abstinence rate

    3 months

  • Self-reported 7-day point-prevalence smoking abstinence rate

    6 months

  • Self-reported smoking reduction rate

    3 months

  • Self-reported smoking reduction rate

    6 months

  • Self-reported quit attempt rate

    3 months

  • +3 more secondary outcomes

Study Arms (2)

Mobile-assisted brief intervention

EXPERIMENTAL
Behavioral: Brief cessation advice + self-help bookletBehavioral: Opt-out referralBehavioral: Mobile chat messaging

Brief advice

ACTIVE COMPARATOR
Behavioral: Brief cessation advice + self-help booklet

Interventions

Brief cessation advice + self-help bookletBEHAVIORAL

Participants will receive brief cessation advice following the AWARD (ask, warn, advise, refer, do-it-again) model and a 24-page self-help booklet.

Brief adviceMobile-assisted brief intervention
Opt-out referralBEHAVIORAL

Research personnel will assist the participant in signing up for the I Quit Programme to receive additional cessation support, unless they decline

Mobile-assisted brief intervention
Mobile chat messagingBEHAVIORAL

Participants will receive personalised chat-based support delivered by a live counsellor for 3 months via WhatsApp. The message will incorporate behaviour change techniques for smoking cessation and mindfulness principles to strengthen participants' capacity to quit smoking.

Mobile-assisted brief intervention

Eligibility Criteria

Age21 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Aged 21 to 80 years
  • Smoked at least one cigarette daily
  • Able to communicate and read in English or Chinese
  • Own a smartphone with WhatsApp installed

You may not qualify if:

  • Exposed to any smoking cessation treatment in the past 3 months
  • Pregnant women

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National University of Singapore

Singapore, Singapore

RECRUITING

MeSH Terms

Conditions

SmokingTobacco Use CessationSmoking Cessation

Condition Hierarchy (Ancestors)

BehaviorHealth Behavior

Study Officials

  • Tzu Tsun Luk, PhD, RN

    National University of Singapore

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Tzu Tsun Luk, PhD, RN

CONTACT

65-66015938luktt@nus.edu.sg

Joey TW Tyoh, BSc, RN

CONTACT

joey.tyoh@nus.edu.sg

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

January 22, 2026

First Posted

January 29, 2026

Study Start

February 4, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

March 31, 2027

Last Updated

April 9, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations

SG(1)