Ultrasound-Guided Dextrose Hydrodissection of the Median Nerve

NCT07371221 | Completed

• 1 other identifier: 2024-KAEK-09
• Study Type: interventional
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate the clinical and ultrasonographic outcomes of ultrasound-guided median nerve hydrodissection with 5% dextrose in patients with mild and moderate carpal tunnel syndrome. The main questions it aims to answer are:

• Does ultrasound-guided dextrose hydrodissection improve pain and functional status in patients with carpal tunnel syndrome?
• Does this procedure lead to changes in ultrasonographic parameters of the median nerve?
• Is ultrasound-guided dextrose hydrodissection a safe procedure in this patient population? Participants will:
• Undergo a single session of ultrasound-guided median nerve hydrodissection with 5% dextrose
• Be evaluated before the procedure and at 1-month and 3-month follow-up visits using clinical outcome measures and ultrasound assessment
• Be monitored for any procedure-related adverse events

Conditions

Carpal Tunnel Syndrome (CTS)

Keywords

carpal tunnel syndrome; hydrodissection; Microvascular imaging; ultrasound guided injection; median nerve

Outcome Measures

Primary Outcomes (1)

• Change in Visual Analog Scale

  The severity of pain in the fingers over the past week was measured using a 10-cm Visual Analog Scale (VAS) ranging from 0 (no pain) to 10 (worst imaginable pain).

  Baseline, 1 month and 3 months

Secondary Outcomes (3)

• Change in Vascularity Index of the Median Nerve

  Baseline, 1 month and 3 months

• Change in median nerve cross-sectional area

  Baseline, 1 month and 3 months

• Change in Boston Carpal Tunnel Questionnaire

  Baseline, 1 month and 3 months

Study Arms (1)

Ultrasound-Guided Dextrose Median Nerve Hydrodissection

EXPERIMENTAL

Participants in this arm undergo a single session of ultrasound-guided median nerve hydrodissection using 5% dextrose solution. The procedure is performed under aseptic conditions with real-time ultrasound guidance to visualize the median nerve and surrounding anatomical structures within the carpal tunnel. The injectate is administered to mechanically separate the median nerve from adjacent tissues.

Procedure: Ultrasound-Guided Median Nerve Hydrodissection with 5% Dextrose

Interventions

Ultrasound-Guided Median Nerve Hydrodissection with 5% Dextrose PROCEDURE

This intervention consists of a single-session ultrasound-guided hydrodissection of the median nerve using 5% dextrose solution in patients with mild and moderate carpal tunnel syndrome. The procedure is performed under aseptic conditions by trained physicians using a high-frequency linear ultrasound transducer. Real-time in-plane imaging is used to visualize the median nerve and surrounding structures, and the injectate is administered via an ulnar approach to mechanically separate the median nerve from adjacent connective tissues within the carpal tunnel. Participants are monitored for any procedure-related adverse events during and after the intervention.

Ultrasound-Guided Dextrose Median Nerve Hydrodissection

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 and 65 years
• Electrophysiologically confirmed mild to moderate CTS on electroneuromyography (ENMG)
• Paresthesia or dysesthesia that worsens at night or with repetitive wrist movement
• Presence of at least one of the following clinical findings:
• Numbness in the median nerve distribution
• Decreased hand strength or thenar muscle weakness
• Positive Phalen's test and/or Tinel's sign
• Pain intensity of ≥3 on the Visual Analog Scale (VAS)

You may not qualify if:

• Previous carpal tunnel surgery
• Severe CTS on ENMG
• Polyneuropathy
• Pregnancy
• Injections in the same area within the last 3 months
• Peripheral nerve injury, thoracic outlet syndrome, cervical radiculopathy, brachial plexopathy
• Traumatic hand injury in the last 2 years
• Inflammatory rheumatological disease
• Thyroid and autoimmune disease

Sponsors & Collaborators

• Dr. Nafiz Korez Sincan State Hospital: lead

Study Sites (1)

Dr. Nafiz Korez Sincan State Hospital

Ankara, Ankara, 06340, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Carpal Tunnel Syndrome

Interventions

Glucose

Condition Hierarchy (Ancestors)

Median Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Nerve Compression Syndromes; Cumulative Trauma Disorders; Sprains and Strains; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Officials

• Suheyla Dal Erdogan, Medical Doctor

  Dr. Nafiz Korez Sincan State Hospital

  STUDY CHAIR

• Sevgi Esra Ozdemir Tekes

  Dr. Nafiz Korez Sincan State Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Model Details: This is a single-arm, prospective, non-randomized interventional study. All participants receive ultrasound-guided median nerve hydrodissection with 5% dextrose, and outcomes are measured before and after the intervention.

Study Record Dates

• First Submitted: January 19, 2026
• First Posted: January 27, 2026
• Study Start: June 17, 2024
• Primary Completion: June 26, 2025
• Study Completion: June 26, 2025
• Last Updated: January 30, 2026

Record last verified: 2026-01

Locations

TU (1)