NCT07371130

Brief Summary

After tooth extraction, a progressive alveolar bone resorption is observed. Alveolar ridge preservation consists of placing a biomaterial within the extraction socket and covering it with a membrane. This procedure helps limit physiological bone resorption, making the soft and hard tissue profile of the edentulous site more prosthetically favorable.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 18, 2026

Completed
9 days until next milestone

First Posted

Study publicly available on registry

January 27, 2026

Completed
19 days until next milestone

Study Start

First participant enrolled

February 15, 2026

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2026

Completed
Last Updated

February 5, 2026

Status Verified

February 1, 2026

Enrollment Period

3 months

First QC Date

January 18, 2026

Last Update Submit

February 4, 2026

Conditions

Tooth AvulsionTooth Crown Fracture

Keywords

alveolar ridge preservationalveolar preservationbone lossbone preservation

Outcome Measures

Primary Outcomes (2)

  • VAS

    Postoperative pain assessment using the Visual Analog Scale (VAS) (1-10)

    1 day , 3 days , 7 days ,14 days

  • Analgesic consumption

    recorded as the number of ibuprofen 400 mg tablets taken

    7 days

Secondary Outcomes (1)

  • Histological Evaluation

    4- 6 month

Study Arms (2)

Traditional Alveolar Preservation

ACTIVE COMPARATOR

The socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and dermal membrane

Procedure: Socket Preservation

therapeutic wavelengths Alveolar Preservation

EXPERIMENTAL

Therapeutic wavelengths are applied as part of the alveolar preservation protocol. The extraction socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and subsequently covered with a dermal membrane to support healing and tissue regeneration.

Procedure: Socket Preservation

Interventions

Socket PreservationPROCEDURE

After atraumatic tooth extraction, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration.

Traditional Alveolar Preservationtherapeutic wavelengths Alveolar Preservation

Eligibility Criteria

Age21 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults in good general health
  • Indication for tooth extraction in sites planned for delayed implant placement
  • Inability to place immediate post-extraction implants due to insufficient residual bone to ensure primary stability
  • Extraction sockets presenting absence of the buccal (vestibular) bone wall
  • Signed informed consent

You may not qualify if:

  • Systemic conditions affecting bone healing
  • Uncontrolled periodontal disease
  • Smoking \>10 cigarettes/day
  • Pregnancy or lactation
  • Use of medications interfering with bone metabolism

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Tooth AvulsionBone Diseases, Metabolic

Condition Hierarchy (Ancestors)

Tooth InjuriesTooth DiseasesStomatognathic DiseasesWounds and InjuriesBone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Giuseppe D'Albis, Dr.

    University of Bari Aldo Moro

    PRINCIPAL INVESTIGATOR

  • Domenico Patarino, Dr.

    Private Practice

    PRINCIPAL INVESTIGATOR

  • Saverio Capodiferro, Prof. Dr.

    University of Bari Aldo Moro

    STUDY DIRECTOR

Central Study Contacts

Giuseppe D'Albis, Dr.

CONTACT

+393495103642giuseppe.dalbis@uniba.it

Domenico Patarino, Dr.

CONTACT

+393394359824domenico.patarino@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
CARE PROVIDER
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr

Study Record Dates

First Submitted

January 18, 2026

First Posted

January 27, 2026

Study Start

February 15, 2026

Primary Completion

May 1, 2026

Study Completion

May 1, 2026

Last Updated

February 5, 2026

Record last verified: 2026-02