Silver Sulfadiazine With Hyaluronic Acid Versus Silver Sulfadiazine Alone in Partial-Thickness Burns

NCT07367087 | Not Yet Recruiting

• 1 other identifier: SSDHA-PTB-2026
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Partial-thickness burns are commonly treated with topical silver sulfadiazine; however, its use may delay epithelialization due to cytotoxic effects on regenerating cells. Hyaluronic acid has biological properties that may enhance wound healing when combined with silver sulfadiazine. This study aims to compare the time to re-epithelialization between silver sulfadiazine combined with hyaluronic acid and silver sulfadiazine alone in patients with bilateral partial-thickness burns using an intra-patient randomized controlled design.

Conditions

Partial-Thickness Burn, Thermal Burn

Outcome Measures

Primary Outcomes (1)

• Time to Complete Re-epithelialization

  Time (in days) from initiation of topical treatment to complete re-epithelialization of the partial-thickness burn wound, defined as full epithelial cover without exudate.

  Up to 21 days

Study Arms (2)

Silver Sulfadiazine Plus Hyaluronic Acid

EXPERIMENTAL

Intra-patient burn areas treated with topical silver sulfadiazine combined with hyaluronic acid.

Drug: Silver Sulfadiazine With Hyaluronic Acid

Silver Sulfadiazine Alone

ACTIVE COMPARATOR

Intra-patient burn areas treated with topical silver sulfadiazine alone.

Drug: Silver Sulfadiazine

Interventions

Silver Sulfadiazine DRUG

Topical application of silver sulfadiazine applied once daily until complete re-epithelialization.

Silver Sulfadiazine Alone

Silver Sulfadiazine With Hyaluronic Acid DRUG

Topical application of silver sulfadiazine combined with hyaluronic acid applied once daily until complete re-epithelialization.

Silver Sulfadiazine Plus Hyaluronic Acid

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with acute bilateral partial-thickness (second-degree) thermal burns where both sides/areas are comparable and suitable for intra-patient treatment (one area treated with SSD+HA and the contralateral area with SSD alone)
• Presentation within 72 hours of burn injury
• Small to moderate total burn surface area suitable for conservative topical management
• Burn wounds not requiring immediate excision or grafting at baseline
• Ability to comply with daily dressing application and follow-up until complete re-epithelialization
• Written informed consent from patient; for minors, parent/guardian consent and assent where applicable

You may not qualify if:

• Full-thickness (third-degree) burns or mixed-depth burns in the study areas
• Chemical, electrical, radiation, or inhalational burns requiring ICU or ventilatory support
• Infected burn wounds at baseline requiring systemic antibiotics
• Major comorbidities likely to impair wound healing (e.g., uncontrolled diabetes, severe peripheral vascular disease, immunosuppression, severe malnutrition)
• Known hypersensitivity to silver sulfadiazine, sulfonamides, hyaluronic acid, or formulation components
• Pregnancy or lactation (as per institutional policy)
• Non-comparable bilateral burn wounds
• Concurrent participation in another interventional wound or burn study

Sponsors & Collaborators

• Dr Muhammad Naveed Shahzad: lead

Study Sites (1)

Nishtar Medical University & Hospital, Multan

Multan, Punjab Province, 60000, Pakistan

Location

MeSH Terms

Interventions

Silver Sulfadiazine; Hyaluronic Acid

Intervention Hierarchy (Ancestors)

Sulfadiazine; Benzenesulfonamides; Sulfonamides; Amides; Organic Chemicals; Sulfanilamides; Aniline Compounds; Amines; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Sulfones; Sulfur Compounds; Glycosaminoglycans; Polysaccharides; Carbohydrates

Study Officials

• Muhammad N Shahzad, MBBS, MCPS,FCPS,FCPS

  Department of Plastic Surgery, Nishtar Medical University / Nishtar Hospital Multan

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Muhammad N Shahzad, MBBS, MCPS,FCPS,FCPS

CONTACT

+92-331-7020877; drnaveedkhanlodhi@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor of Plastic Surgery

Model Details: Intra-patient randomized controlled design in which each participant receives both interventions applied to bilateral burn wounds.

Study Record Dates

• First Submitted: January 16, 2026
• First Posted: January 26, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: January 26, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)