Effect of Combined Adductor Canal and AFCN Block on Postoperative Inflammation

NCT07367009 | Not Yet Recruiting

• 1 other identifier: FSMTRH-ST-01
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this thesis is to evaluate the effects of adding an anterior femoral cutaneous nerve (AFCN) block to the adductor canal block used for postoperative analgesia after total knee arthroplasty on the postoperative inflammatory response, as assessed by inflammatory biomarkers including NLR, PLR, AISI, and CAR.

Conditions

Total Knee Anthroplasty

Keywords

total knee arthroplasty; adductor canal block; anterior femoral cutaneous nerve block; postoperative analgesia; inflammatory biomarkers

Outcome Measures

Primary Outcomes (1)

• assessment of post operative inflammatuar markes

  The primary objective of this observational study is to evaluate the effect of adding an anterior femoral cutaneous nerve block to the adductor canal block on the inflammatory response, as assessed by biomarkers such as NLR, PLR, AISI, and CAR, in patients undergoing total knee arthroplasty.

  it will be recorded at 0, 15, and 30 minutes in the PACU, and at 2, 4, 8, 12, and 24 hours on the ward.

Secondary Outcomes (1)

• postoperative opioid consumption, wound healing

  it will be recorded at 0, 15, and 30 minutes in the PACU, and at 2, 4, 8, 12, and 24 hours on the ward.

Study Arms (2)

patients who peripheral nerve block applied

patients who adductor canal block and anterior femoral cutaneous nerve block applied

patients without peripheral nerve block

patients who do not receive adductor canal block and anterior femoral cutaneous nerve block

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 18 years and older, scheduled for elective unilateral total knee arthroplasty under spinal anesthesia (SA), classified as American Society of Anesthesiologists (ASA) physical status I-III, and who provided written informed consent after being informed one day before surgery on the ward, will be included.

You may qualify if:

• Patients scheduled for elective unilateral total knee arthroplasty under spinal anesthesia
• Aged 18 years and older
• Body mass index (BMI) \<40 kg/m²
• ASA physical status I-III
• Provision of written informed consent

You may not qualify if:

• Revision or bilateral surgery
• General anesthesia or conversion to general anesthesia due to failed block
• BMI ≥40 kg/m²
• ASA physical status \>III
• Local infection, hematoma, previous surgery, or deformity at the block site
• Coagulopathy or history of hematologic, renal, or hepatic disease; advanced respiratory or cardiac failure; malignancy
• Use of anticoagulant therapy
• History of local anesthetic allergy or toxicity
• Impaired cooperation, Alzheimer's disease, dementia, psychiatric or neurological disorders, or language/communication barriers
• Chronic analgesic use, chronic alcohol consumption, or substance abuse
• Refusal to participate in the study

Sponsors & Collaborators

• Fatih Sultan Mehmet Training and Research Hospital: lead

Study Sites (1)

Fatih Sultan Mehmet Training and Research Hospital

Istanbul, ataşehir, 34752, Turkey (Türkiye)

Location

Related Publications (3)

• Razzaz M.; Youssif G.; Wahba S.; Mohamed S.; Mohamed A. Analgesic efficacy of ultrasound guided anterior femoral cutaneous nerve block (AFCNB) plus femoral triangle block (FTB) vs. adductor canal block (ACB) in total knee arthroplasty, Anaesthesia, Pain & Intensive Care, 2025

  BACKGROUND

• Domagalska M, Ciftsi B, Janusz P, Reysner T, Kolasinski J, Wieczorowska-Tobis K, Kowalski G. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels following erector spinae plane block (ESPB) in posterior lumbar decompression: a randomized, controlled trial. Eur Spine J. 2023 Dec;32(12):4192-4199. doi: 10.1007/s00586-023-07913-z. Epub 2023 Sep 5.

  PMID: 37668689 RESULT

• Domagalska M, Reysner T, Kowalski G, Daroszewski P, Mularski A, Wieczorowska-Tobis K. Pain Management, Functional Recovery, and Stress Response Expressed by NLR and PLR after the iPACK Block Combined with Adductor Canal Block for Total Knee Arthroplasty-A Prospective, Randomised, Double-Blinded Clinical Trial. J Clin Med. 2023 Nov 14;12(22):7088. doi: 10.3390/jcm12227088.

  PMID: 38002702 RESULT

Study Officials

• oznur demiroluk, as prof

  fatih sultan mehmet traing and research hospital

  STUDY DIRECTOR

Central Study Contacts

selin tasci

CONTACT

+905458374041; selinkrty5@gmail.com

oznur demiroluk

CONTACT

+905335229508; onrdemiroluk@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor

Study Record Dates

• First Submitted: January 17, 2026
• First Posted: January 26, 2026
• Study Start: January 19, 2026
• Primary Completion (Estimated): January 20, 2027
• Study Completion (Estimated): January 30, 2027
• Last Updated: January 28, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)