Effect of Prebiotic Sodas on Postprandial Levels of GLP-1, PYY, Transit Time and Satiety Levels: A Pilot Study

NCT07362563 | Recruiting

• 1 other identifier: INQ-2534
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of this study is to evaluate the acute effects of prebiotic sodas on postprandial levels of glucagon-like peptide-1 (GLP-1), peptide YY (PYY), gastric emptying, and satiety levels in healthy adults.

Conditions

Satiety in Healthy Volunteers

Outcome Measures

Primary Outcomes (1)

• Blood GLP-1 iAUC

  Incremental area under the curve (iAUC) for GLP-1 from immediately prior to test-product consumption (t=0) to t=120 min following test-product consumption.

  For 2 hours post intervention

Secondary Outcomes (3)

• Blood PYY iAUC

  For 2 hours post intervention

• Gastric Emptying Rate/Transit Time via Acetaminophen

  Oral dose of acetaminophen with blood samples taken for 2 hours post intervention

• Change in Perceived Satiety Levels

  For 2 hours post intervention

Study Arms (4)

Control Soda

PLACEBO COMPARATOR

Participants will consume one 12 oz can of a control soda

Other: Control Soda

Prebiotic Soda - Shelf Stable

EXPERIMENTAL

Participants will consume one 12 oz can of the shelf stable prebiotic soda

Other: Prebiotic Soda - Shelf Stable

Prebiotic Soda - Refrigerated

EXPERIMENTAL

Participants will consume one 12 oz can of the refrigerated prebiotic soda

Other: Prebiotic Soda - Refrigerated

Prebiotic Soda - Shelf Stable + Functional Ingredient

EXPERIMENTAL

Participants will consume one 12 oz can of the shelf stable prebiotic soda with an added functional ingredient

Other: Prebiotic Soda - Shelf Stable + Functional Ingredient

Interventions

Control Soda OTHER

Participants will consume one 12 oz can of a control soda that contains 0 g dietary fiber and 4 g total sugar.

Control Soda

Prebiotic Soda - Shelf Stable OTHER

Participants will consume one 12 oz can of a shelf stable prebiotic soda that contains 6 g dietary fiber and 4 g total sugar.

Prebiotic Soda - Shelf Stable

Prebiotic Soda - Refrigerated OTHER

Participants will consume one 12 oz can of a shelf stable prebiotic soda that contains 9 g dietary fiber and 4 g total sugar.

Prebiotic Soda - Refrigerated

Prebiotic Soda - Shelf Stable + Functional Ingredient OTHER

Participants will consume one 12 oz can of a shelf stable prebiotic soda that contains 6 g dietary fiber, 4 g total sugar, and an added functional ingredient.

Prebiotic Soda - Shelf Stable + Functional Ingredient

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 18-60 years, inclusive.
• BMI between 18.0 and 30.0 kg/m2.
• Stable weight in the last 3 months (+/-5kg).
• Willing to abstain from unusual strenuous exercise, consuming alcoholic drinks and from taking fiber supplements for 24 hours before study days.
• Willing to refrain from smoking tobacco or e-cigarettes, and using marijuana in any form for 12h before and during study visits.
• Understanding the study procedures and willing to provide informed consent to participate in the study and authorization to release relevant protected health information to the study investigator.
• Subjects must be eligible to receive income in Canada and be covered by a health insurance plan such as Ontario Health Insurance Plan (OHIP).

You may not qualify if:

• Self-reported pregnant or breastfeeding women.
• Subjects with a history of severe food allergies or an allergy to acetaminophen.
• Known history of diabetes, any gastrointestinal disorder that alters the absorption of nutrients, liver disease, or the presence of any health condition, illness or drug use that increases risk to the subject or to others or may affect the results, as judged by the Qualified Investigator (QI).
• Subjects who are currently or in the last 2 months have been on oral or injectable GLP-1 receptor agonist (RA) medications.
• Subjects who consume more than 14 alcoholic drinks per week, or more than 5 alcoholic drinks on any one occasion.
• Subjects who have been on antibiotic therapy in the last 2 months.
• Subjects taking the blood thinning drug warfarin.
• Subjects who are habitual users of the following supplements in the past 30 days: berberine, curcumin, cinnamon, resveratrol, and gardenia.
• Subjects which have undergone major surgery in the last 3 months.
• Unwillingness or inability to comply with experimental procedures and to follow Inquis safety guidelines.
• Subject is currently participating or recently (within 30 days of screening) participated in a clinical trial involving long-term exposure (greater than 24 hours) to an investigational drug, nutritional supplement, or lifestyle modification.

Sponsors & Collaborators

• Olipop, PBC: lead
• INQUIS Clinical Research: collaborator

Study Sites (1)

Inquis Clinical Research

Toronto, Ontario, M5C 2N8, Canada

RECRUITING

MeSH Terms

Interventions

sodium bicarbonate-based toothpaste

Study Officials

• Janice Campbell

  INQUIS Clinical Research

  STUDY DIRECTOR

Central Study Contacts

Director of Clinical Operations

CONTACT

416-861-0506; jcampbell@inquis.com

Senior Scientist

CONTACT

416-861-9782; alexandrajenkins@inquis.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 9, 2026
• First Posted: January 23, 2026
• Study Start: January 1, 2026
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: January 28, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)