NCT07359131

Brief Summary

The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders. The study includes adult patients who underwent TMJ surgery and received either PRP or PRF intraoperatively. The main questions this study aims to answer are: Whether intraoperative PRP or PRF injection is associated with differences in postoperative pain intensity and recovery. Whether PRP and PRF differ in their effects on postoperative jaw function, including maximum mouth opening and joint symptoms. If there is a comparison group: Researchers will compare patients who received intraoperative PRP with those who received intraoperative PRF to assess differences in postoperative pain, functional outcomes, and joint-related symptoms. Participants will: Have their existing medical records reviewed retrospectively. Provide postoperative outcome data derived from routine clinical follow-up, with no prospective recruitment or intervention.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
700

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2026

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 14, 2026

Completed
1 day until next milestone

Study Start

First participant enrolled

January 15, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

January 22, 2026

Completed
9 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2026

Completed
5 days until next milestone

Study Completion

Last participant's last visit for all outcomes

February 5, 2026

Completed
Last Updated

January 23, 2026

Status Verified

January 1, 2026

Enrollment Period

16 days

First QC Date

January 14, 2026

Last Update Submit

January 21, 2026

Conditions

Temporomandibular Joint Disorders

Outcome Measures

Primary Outcomes (1)

  • pain intensity

    The primary endpoint of the study is the change in pain intensity from baseline to 6 months post-surgery.

    from baseline to 6 months post-surgery.

Secondary Outcomes (1)

  • maximum unassisted opening (MMO)

    baseline and various follow-up times in 6 months.

Study Arms (3)

Group 1 - Platelet-Rich Plasma injection therapy group

Patients who received Platelet-Rich Plasma injections during surgery.

Group 2 - Platelet-Rich Fibrin injection therapy group

Patients who are receiving Platelet-Rich Fibrin injections during surgery.

Group 3 - non injection therapy group

Patients who are not receiving Platelet-Rich Plasma nor Platelet-Rich Fibrin injections during surgery.

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study population consists of adult patients aged 18 to 75 years who underwent unilateral or bilateral temporomandibular joint arthroscopy at a single institution. All patients received intraoperative intra-articular injection of platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) as part of routine clinical care. This is a retrospective observational study based on review of existing medical records, with no prospective recruitment or intervention.

You may qualify if:

  • Patients aged 18 to 75 years (inclusive)
  • Underwent unilateral or bilateral temporomandibular joint (TMJ) arthroscopy
  • Received intraoperative platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injection during TMJ arthroscopy

You may not qualify if:

  • Age younger than 18 years or older than 75 years
  • Did not undergo TMJ arthroscopy
  • Did not receive intraoperative PRP or PRF injection
  • Incomplete clinical or follow-up data

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Meikun Wang

Boston, Massachusetts, 02114, United States

Location

MeSH Terms

Conditions

Temporomandibular Joint Disorders

Condition Hierarchy (Ancestors)

Craniomandibular DisordersMandibular DiseasesJaw DiseasesMusculoskeletal DiseasesJoint DiseasesMuscular DiseasesStomatognathic Diseases

Central Study Contacts

Jingping Wang, MD PhD

CONTACT

6179369136jwang23@mgh.harvard.edu

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Associate Professor Staff Anesthesiologist & Pain Physician

Study Record Dates

First Submitted

January 14, 2026

First Posted

January 22, 2026

Study Start

January 15, 2026

Primary Completion

January 31, 2026

Study Completion

February 5, 2026

Last Updated

January 23, 2026

Record last verified: 2026-01

Locations

US(1)