Effect of Transcutaneous Electrical Stimulation on Peripheral Blood Flow

NCT07354607 | Recruiting

• 2 other identifiers: CHMS250102025-A02335-44
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation can affect blood flow in healthy volunteers. The main question it aims to answer is: Determine the stimulation parameters (frequency in the range 5- 100Hz and proximal or distal placement) inducing the most significant hyperaemic response in volunteers. Participants will attend to one visit ( 1h30) , 6 protocol of stimulation will be tested on his arm . If his agree, an optionnal measure will be made during another visit. During this optionnal visit, two modalities of intensity adjustment will be tested in regard of the result of the first part of the study.

Conditions

Volunteer; Adult

Keywords

transcutaneous electrical nerve stimulation; blood flow

Outcome Measures

Primary Outcomes (1)

• stimulation parameters that induce the most significant hyperaemic response

  Determine the stimulation parameters (frequency in the range 5- 100Hz and proximal or distal placement) that induce the most significant hyperaemic response in volunteers.

  from enrollment to the end of the procedure (1h30)

Secondary Outcomes (3)

• Assess the score on a scale of disconfort level during stimulation for each condition

  during testing procedure

• Compare stimulation intensities between each condition

  during testing procedure

• Compare muscle metabolic demand between each condition

  during testing procedure

Other Outcomes (2)

• ancillary : Compare blood flow kinetics during long-term stimulation (1 hour) according to the modalities of intensity adjustment over time (no adjustment vs. adjustment).

  during testing procedure (second visit)

• ancillary : Compare the comfort reported by participants during long-term stimulation based on the methods used to adjust intensity over time (no adjustment vs. adjustment).

  during testing procedure (second visit)

Study Arms (1)

experimental group

EXPERIMENTAL

transcutaneous electrical nerve stimulation

Other: transcutaneous electrical nerve stimulation

Interventions

transcutaneous electrical nerve stimulation OTHER

transcutaneous electrical nerve stimulation on arm. 6 different protocol will be apply testing different modality of frequency and positionnement of electrodes

experimental group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subject aged 18 years or older
• Having freely given written consent, after being informed of the purpose of the study, its conduct and its risks.
• Affiliated with a social security scheme

You may not qualify if:

• Persons with pacemakers or any other implantable electrical devices,
• Pregnant women
• Suffering from dermatological conditions or muscle/skin lesions on the arms and forearms.
• Participant unable to give free and informed consent.
• Participant unable to comply with the specific procedures of the study.
• Participant deprived of liberty or benefiting from legal protection measures.

Sponsors & Collaborators

• Laboratoire Interuniversitaire de Biologie de la Motricité: collaborator
• Université Savoie Mont Blanc: collaborator
• Centre Hospitalier Metropole Savoie: lead

Study Sites (1)

Centre Hospitalier Métropole Savoie

Chambéry, 73000, France

RECRUITING

MeSH Terms

Interventions

Transcutaneous Electric Nerve Stimulation

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Physical Therapy Modalities; Rehabilitation; Analgesia; Anesthesia and Analgesia

Central Study Contacts

leo blervaque

CONTACT

+33 4 79 96 59 10; leo.blervaque@ch-metropole-savoie.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 30, 2025
• First Posted: January 21, 2026
• Study Start: February 4, 2026
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: March 10, 2026

Record last verified: 2026-03

Locations

FR (1)