NCT07349498

Brief Summary

This is a prospective, multicenter observational study for recipients of hematopoietic stem cell transplantation. Patients who underwent hematopoietic stem cell transplantation at the participating centers will be entrolled in the study. The clinical characteristics, laboratory profiles, management measures, and clinical outcomes such as post-transplant cardiovascular events will be prospectively collected.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10,000

participants targeted

Target at P75+ for all trials

Timeline
127mo left

Started Jan 2026

Longer than P75 for all trials

Geographic Reach
1 country

16 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress5%
Jan 2026Dec 2036

Study Start

First participant enrolled

January 1, 2026

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

January 9, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

January 16, 2026

Completed
10.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2036

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2036

Last Updated

January 16, 2026

Status Verified

January 1, 2026

Enrollment Period

10.5 years

First QC Date

January 9, 2026

Last Update Submit

January 9, 2026

Conditions

Transplant ComplicationCardiovascular EventsHematopoietic Stem Cell Transplantation

Outcome Measures

Primary Outcomes (1)

  • Major adverse cardiovascular events (MACE)

    Major adverse cardiovascular events (MACE) after hematopoietic stem cell transplantation.

    At 30 days, 100 days, 3 months, 6 months, 1 years, 3 years, 5 years post hematopoietic stem cell transplantation.

Secondary Outcomes (4)

  • Cardiovascular events

    At 30 days, 100 days, 3 months, 6 months, 1 years, 3 years, 5 years post hematopoietic stem cell transplantation.

  • Overall survival

    At 30 days, 100 days, 3 months, 6 months, 1 years, 3 years, 5 years post hematopoietic stem cell transplantation.

  • Event-free survival

    At 30 days, 100 days, 3 months, 6 months, 1 years, 3 years, 5 years post hematopoietic stem cell transplantation.

  • Complications of hematopoietic stem cell transplantation

    At 30 days, 100 days, 3 months, 6 months, 1 years, 3 years, 5 years post hematopoietic stem cell transplantation.

Study Arms (1)

Patients undergoing hematopoietic stem cell transplantation

Patients who undergo allogeneic hematopoietic stem cell transplantation at participating medical center.

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients who undergo hematopoietic cell transplantation at any of the participating medical centers.

You may qualify if:

  • Patients who undergo hematopoietic cell transplantation at any of the participating medical centers.

You may not qualify if:

  • Any other conditions that, in the opinion of the investigator, can interfere with the interpretation of data.
  • Patient request to withdraw from the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (16)

Chinese PLA General Hospital

Beijing, Beijing Municipality, China

RECRUITING

Peking University First Hospital

Beijing, Beijing Municipality, China

RECRUITING

Peking University People's Hospital

Beijing, Beijing Municipality, China

RECRUITING

Peking University Third Hospital

Beijing, Beijing Municipality, China

RECRUITING

Xinqiao hospital of the third military medical university

Chongqing, Chongqing Municipality, China

RECRUITING

Sun Yat-sen University Cancer Center, Sun Yat-sen University

Guangzhou, Guangdong, China

RECRUITING

Peking University Shenzhen Hospital

Shenzhen, Guangdong, China

RECRUITING

First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

RECRUITING

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

RECRUITING

Tongji Hospital, Affiliated to Tongji Medical College of Huazhong University of Science and Technology

Wuhan, Hubei, China

RECRUITING

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

RECRUITING

First Affiliated Hospital Xi'an Jiaotong University

Xi'an, Shaanxi, China

RECRUITING

Sichuan Provincial People's Hospital

Chengdu, Sichuan, China

RECRUITING

Hematology Hospital of Chinese Academy of Medical Sciences (Hematology Research Center of Chinese Academy of Medical Sciences)

Tianjin, Tianjin Municipality, China

RECRUITING

First Affiliated Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, China

RECRUITING

First Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China

RECRUITING

Central Study Contacts

Xiao Hui Zhang

CONTACT

861088324577zhangxh@bjmu.edu.cn

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
5 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

January 9, 2026

First Posted

January 16, 2026

Study Start

January 1, 2026

Primary Completion (Estimated)

June 30, 2036

Study Completion (Estimated)

December 31, 2036

Last Updated

January 16, 2026

Record last verified: 2026-01

Locations

CN(16)