Comparing of Sesame Oil, Nitroglycerin Ointment, and Aloe Vera Gel

NCT07346677 | Not Yet Recruiting Phase 2

• 1 other identifier: Prevention of Phlebitis
• Study Type: interventional
• Target: 190
• Locations: 0 countries
• Sites: N/A

Brief Summary

compare the effectiveness sesame oil, aloe Vera gel, and nitroglycerin ointment prevention of phlebitis.

Conditions

Cancer; Chemotherapy

Keywords

sesame oil; aloe Vera gel; nitroglycerin ointment; phlebitis

Outcome Measures

Primary Outcomes (1)

• Phlebitis Scale

  Multiple measurements will be aggregated to arrive at one reported value (phlebitis) that consists of five symptom grades were included in the chemotherapy-induced phlebitis severity scale, ranging from zero to four in severity. The National Cancer Institute Common Terminology Criteria for Adverse Events version 4 (NCI-CTCAE) (41). Which is widely used by clinical oncologists, served as the basis for the selection of grading levels. Grade zero denotes no symptoms); (grade one mild), ( grade two moderate), ( grade three marked) (and grade four severe).

  24-48 hours

Study Arms (4)

sesame oil

EXPERIMENTAL

Sesame oil application is advised as a standard hospital treatment for patients receiving chemotherapy. It is possible to conduct a similar study with a large probability sample and in a variety of settings, allowing for greater generalization of the findings. The researchers will be applied 10 drops (3 mL) of 100% pure sesame oil in a circular motion for 5 minutes within 10 cm on the anterior forearm of the chemotherapy patient. They then gradually spread the oil around 10 cm toward the arm of the study group to improve absorption. Each 12 hours wasapplied 2-time morning and night. Record the frequency of phlebitis in the 24 and 48 hours after the intervention.

Biological: Sesame Oil

Aloe Vera gel

EXPERIMENTAL

The researcher will soak the skin in 5 cc of Aloe vera gel, drawn with a syringe, in a circular motion for 20 minutes within 10 cm on the anterior forearm of the chemotherapy patient. They then gradually spread the gel around 10 cm toward the arm of the study group to improve absorption. Each 12 hours, 2 time morning and night, record the frequency of phlebitis in the 24 hours after the intervention.

Biological: Aloe vera gel

nitroglycerin ointment

EXPERIMENTAL

The researchers will apply nitroglycerin ointment in a circular motion for 5 minutes over a 10 cm area on the anterior forearm of the chemotherapy patient. They then gradually spread the oil around 10 cm toward the arm of the study group to improve absorption. Each 12 hours, a 2-time morning and night record the frequency of phlebitis in the 24 and 48 hours after the intervention.

Biological: nitroglycerin ointment

control

OTHER

without any intervention

Other: Control

Interventions

Sesame Oil BIOLOGICAL

10 drops (3 mL) of 100% pure sesame oil in a circular motion for 5 minutes within 10 cm on the anterior forearm of the chemotherapy patient. T

Also known as: Yellow

sesame oil

Aloe vera gel BIOLOGICAL

soak the skin in 5 cc of Aloe vera gel, drawn with a syringe, in a circular motion for 20 minutes within 10 cm on the anterior forearm of the chemotherapy patient.

Also known as: green

Aloe Vera gel

Control OTHER

without any intervention

Also known as: white

control

nitroglycerin ointment BIOLOGICAL

The researchers will apply nitroglycerin ointment in a circular motion for 5 minutes over a 10 cm area on the anterior forearm of the chemotherapy patient.

nitroglycerin ointment

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• adult conscious patients of both gender.
• Patients receiving chemotherapy antimetabolites (5-fluorouracil).
• Patients receiving chemotherapy alkylating agents (Cisplatin).
• Patients receiving chemotherapy through peripheral IV cannula.
• Patients breast cancer colon cancer.

You may not qualify if:

• Phlebitis has already appeared at the IV infusion site.
• Patients using port or central venous catheters to administer chemotherapy. - Patient radiation therapy, immunity therapy and palliative therapy
• Patients receiving chemotherapy (antitumor antibiotics, plant alkaloids).

Sponsors & Collaborators

• University of Baghdad: collaborator
• University of Basrah: lead

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MeSH Terms

Conditions

Neoplasms; Phlebitis

Interventions

Sesame Oil; Aloe vera gel; Green Or

Condition Hierarchy (Ancestors)

Peripheral Vascular Diseases; Vascular Diseases; Cardiovascular Diseases; Vasculitis

Intervention Hierarchy (Ancestors)

Dietary Fats, Unsaturated; Dietary Fats; Fats; Lipids; Fats, Unsaturated; Plant Oils; Oils; Plant Preparations; Biological Products; Complex Mixtures; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Central Study Contacts

Ali Malik Tiryag, Master

CONTACT

+9647811735332; ali.malik@uobasrah.edu.iq

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Model Details: True experimental design (comparative) this type of design allows the researcher to understand the best cause-and-effect relationship between independent variables (sesame oil, aloe Vera gel , nitroglycerin ointment) and dependent variables (phlebitis), among patient receiving chemotherapy(antimetabolites 5- fluorouracil , alkylating agents Cisplatin) and which intervention is more effective

Study Record Dates

• First Submitted: December 6, 2025
• First Posted: January 16, 2026
• Study Start (Estimated): May 11, 2026
• Primary Completion (Estimated): June 20, 2026
• Study Completion (Estimated): July 20, 2026
• Last Updated: April 28, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share