Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct

NCT07345702 | Not Yet Recruiting

• 1 other identifier: BAOCHE-LC
• Study Type: observational
• Target: 518
• Locations: 1 country
• Sites: 1

Brief Summary

This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion. It also investigates clinical, imaging, and laboratory factors associated with functional outcomes and mortality. Patients are grouped according to the treatment received in routine clinical practice.

Conditions

Basilar Artery Occlusion; Ischemic Stroke; Large Core Infarct

Outcome Measures

Primary Outcomes (1)

• Proportion of Patients Achieving mRS 0-3 at 90 Days

  The modified Rankin scale (range, 0 \[no symptoms\] to 6 \[death\]). Higher scores mean a worse outcome.

  90 days

Secondary Outcomes (4)

• Ordinal Shift analysis of mRS at 90 days

  90 days

• Rate of All-Cause Mortality at 90 Days

  90 days

• Rate of Symptomatic Intracranial Hemorrhage

  24 (-2/+12) hours

• Proportion of Patients Achieving mRS 0-3 at 1 year

  1 year

Study Arms (2)

Endovascular Therapy

Procedure: Endovascular Therapy

Best Medical Treatment Alone

Interventions

Endovascular Therapy PROCEDURE

Endovascular therapy performed as part of routine clinical care for acute basilar artery occlusion, including mechanical thrombectomy with stent retriever and/or aspiration. Rescue angioplasty and/or intracranial stenting may be used at the operator's discretion. Peri-procedural management and concomitant medical therapy follow local standard practice.

Endovascular Therapy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults (≥18 years) with imaging-confirmed acute vertebrobasilar occlusion and large-core infarction (pc-ASPECTS 0-5) treated within 7 days of symptom onset/last known well at participating centers in China. Patients are identified retrospectively from routine clinical practice and classified according to treatment received: endovascular therapy plus standard medical management versus standard medical management alone.

You may qualify if:

• Age ≥18 years, men or women.
• Occlusion (TIMI 0-1) of the basilar artery or intracranial segments of both vertebral arteries (V4) as evidenced by CTA/MRA/DSA.
• Time from symptom onset (or last known well) to treatment (endovascular therapy or medical therapy) ≤7 days.
• Patients with large core infarction in the posterior circulation, defined as a posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) score of 0-5 on CT angiography source images or MR with diffusion-weighted imaging or non-contrast CT.

You may not qualify if:

• Subjects with occlusions in both anterior and posterior circulation.
• CT or MR evidence of hemorrhage (the presence of microbleeds on MRI is allowed).
• Missing key clinical information (e.g., unavailable baseline NIHSS, unclear symptom onset/last known well time, or missing major treatment information including whether EVT was performed).
• Baseline NIHSS score \<6.
• Woman of childbearing potential who is known to be pregnant or lactating or who has a positive pregnancy test on admission.
• Missing follow-up outcomes at 90 days.
• Any other condition judged by investigators to substantially affect analysis or interpretation.

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead

Study Sites (1)

Xuanwu Hospital

Beijing, Beijing Municipality, 100053, China

Location

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Chuanhui Li

CONTACT

15210439828; lichuanhui@xwh.ccmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Xuanwu Hospital, Captimal Medical University

Study Record Dates

• First Submitted: January 7, 2026
• First Posted: January 16, 2026
• Study Start: January 31, 2026
• Primary Completion (Estimated): October 31, 2026
• Study Completion (Estimated): October 31, 2026
• Last Updated: January 20, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)