Clinical Effects and Metagenomic Analysis of Using an Air Polishing Device With Erythritol Powder Compared to Scaling and Root Planing in Periodontal Maintenance Therapy.

NCT07344805 | Completed

• 1 other identifier: CEU-Martinez-Gonzalez-Cortell
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Periodontitis is a chronic, multifactorial disease primarily driven by the accumulation of bacterial deposits. Treatment involves the mechanical removal of the biofilm, traditionally performed by scaling and root planing (SRP). However, SRP is time-consuming and can cause irreversible damage to both hard and soft tissues as well as postoperative sensitivity. Consequently, adjunctive or alternative air-polishing devices have been developed. The objective of this study is to compare the clinical and microbiological efficacy of an erythritol-powder air-polishing device versus SRP in periodontal maintenance therapy.To evaluate patient-reported pain and treatment time for erythritol air-polishing versus SRP. A randomized clinical trial was designed and participants were randomly assigned to one of two groups: Intervention: Perio-Flow® (air + erythritol powder) and PIEZON PS®. Control: Ultrasonic debridement followed by SRP with Gracey curettes.At baseline and at six months, probing depth, clinical attachment level, and bleeding on probing were recorded. Saliva samples were collected to detect the most prevalent periodontal pathogens. Patient discomfort during treatment was measured by a visual analog scale, and procedure duration was timed.

Conditions

Periodontitis

Keywords

periodontal maintenance; erythritol; powder air polishing

Outcome Measures

Primary Outcomes (3)

• Improvement of clinical periodontal parameter: clinical attachment level

  Measurement of clinical attachment level in milimeters

  six months

• Improvement of clinical periodontal parameter: probing depth

  Measurement of probing depth in milimeters

  six months

• Improvement of clinical periodontal parameter: bleeding index

  Measurement of bleeding index in percentage.

  six months

Secondary Outcomes (1)

• Changes in periodontal microbiome

  Six months

Other Outcomes (1)

• Patient discomfort

  Six months

Study Arms (2)

Periodontal maintenance with ultrasonic + scaling and root planning

ACTIVE COMPARATOR

Device: Cavitron® ultrasonic scaler

Periodontal maintenance with erythritol air polishing

EXPERIMENTAL

Device: AIRFLOW® Prophylaxis Master

Interventions

AIRFLOW® Prophylaxis Master DEVICE

Periodontal Maintenance with Erythritol Air Polisher in periodontal patients.

Periodontal maintenance with erythritol air polishing

Cavitron® ultrasonic scaler DEVICE

Periodontal maintenance with ultrasonic scaler and manual curettes in periodontal patients.

Periodontal maintenance with ultrasonic + scaling and root planning

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who have received basic periodontal treatment between 3-6 months before the study.

You may not qualify if:

• Pregnant or breastfeeding patients.
• Use of systemic antibiotics within 6 months prior to the study.
• Patients who smoke more than 10 cigarettes/day.
• Uncontrolled diabetic patients.

Sponsors & Collaborators

• Cardenal Herrera University: lead

Study Sites (1)

Universidad CEU Cardenal Herrera

Alfara del Patriarca, Valencia, 46115, Spain

Location

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Isidoro Cortell-Ballester, DDS, MD, PhD

  Cardenal Herrera University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: November 19, 2025
• First Posted: January 15, 2026
• Study Start: July 1, 2023
• Primary Completion: February 1, 2025
• Study Completion: July 1, 2025
• Last Updated: January 15, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)