Blood Flow Restriction Resistance Exercise and Cardiac Cycle Dynamics
1 other identifier
interventional
40
1 country
1
Brief Summary
Blood flow restriction resistance exercise uses partial vascular occlusion of a limb during low weight resistance exercises to stimulate muscle strengthening and growth. This is commonly used during rehabilitation from an injury. Because blood flow in and out of the limbs is decreased, this may have consequences for blood flow through the heart. The purpose of this study will be to test cardiac dynamics during blood flow restriction resistance exercise to determine if cardiac blood flow is impacted. It is hypothesized that both non-BFR exercise and BFR exercise will increase heart rate shortening various cardiac cycle parameters, but BFR exercise will increase the isovolumetric contraction time vs non-BFR exercise due to an increase in total peripheral resistance. It is also hypothesized that BFR exercise will lower early ventricular filling parameters due to lower venous return.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Feb 2026
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 7, 2026
CompletedFirst Posted
Study publicly available on registry
January 15, 2026
CompletedStudy Start
First participant enrolled
February 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
January 1, 2028
February 13, 2026
February 1, 2026
1.9 years
January 7, 2026
February 11, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
Cardiac cycle durations
During the intervention for approximately 10 minutes.
Ventricular filling
During intervention phase for approximately 10 minutes.
Study Arms (1)
Intervention group
EXPERIMENTALBlood flow restriction resistance exercise
Interventions
Blood flow in and out of the limb will be artificially with an occlusion cuff.
Eligibility Criteria
You may qualify if:
- Generally healthy
You may not qualify if:
- Uncontrolled hypertension
- Peripheral vascular disease
- Lymphedema
- Sickle cell anemia
- Heart failure
- Stroke history
- Heart attack history
- Rheumatoid arthritis
- Chronic kidney disease
- Diabetes
- Severe neuropathy
- Any condition that may make blood flow restriction resistance exercise riskier like history of blood clots
- Use of coagulant therapy
- Susceptible to blood clots
- Obesity
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Montclair State University
Montclair, New Jersey, 07043, United States
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 7, 2026
First Posted
January 15, 2026
Study Start
February 1, 2026
Primary Completion (Estimated)
January 1, 2028
Study Completion (Estimated)
January 1, 2028
Last Updated
February 13, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will not share