IV Injection of Metoclopramide With or Without Dexamethasone

NCT07343817 | Not Yet Recruiting Early Phase 1 DMC

• 1 other identifier: Anesthesia Department
• Study Type: interventional
• Target: 1
• Locations: 0 countries
• Sites: N/A

Brief Summary

Reflux and the aspiration of gastric contents have always been important focal points. Previous study stated that trauma is an important factor in aspiration pneumonia. Often, emergency trauma patients have residual gastric contents due to the ingestion of food before injury, the accidental swallowing of nasal and/or oral blood after injury, and delayed gastric emptying due to stress, pain, or the use of opioids. During sedation or general anesthesia, such satiated patients are often at risk of aspiration due to a reduction in lower esophageal sphincter tension and the protective inhibition of the airway reflex. Perioperative gastric ultrasound can be performed at a bedside ultrasound unit; it can safely, non-invasively, conveniently, and effectively evaluate the fullness of a patient's stomach and the nature of their gastric contents. It can also be used in the selection of an appropriate method for the anesthetic induction process and can reduce the risk of vomiting, aspiration, and related complications. As a gastric motility-promoting drug, metoclopramide can accelerate gastric emptying. Dexamethasone reduced the incidence of nausea and vomiting and improve gastric motility.

Conditions

Trauma Injury

Keywords

Poly trauma

Outcome Measures

Primary Outcomes (1)

• Assessment of gastric weight/volume kg/m^2 measured by ultrasonography in traumatic patients.

  Assessment of gastric weight/volume kg/m\^2 by grams measured by ultrasonography in traumatic patients.

  2 years

Study Arms (2)

Metoclopramide

EXPERIMENTAL

Drug used to assessment

Combination Product: Dexamethasone; Diagnostic Test: Ultrasonography assessment

Dexamethasone

EXPERIMENTAL

Drug used to assessment

Combination Product: Dexamethasone; Diagnostic Test: Ultrasonography assessment

Interventions

Dexamethasone COMBINATION_PRODUCT

IV infection

Also known as: Metoclopramide

Dexamethasone; Metoclopramide

Ultrasonography assessment DIAGNOSTIC_TEST

Assessment of gastric motility by ultrasonography

Dexamethasone; Metoclopramide

Eligibility Criteria

• Age: 16 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Traumatic patients undergo emergency operations
• years of age
• cm in height
• Body mass index \<30 kg/m2

You may not qualify if:

• A history of diseases of important organs, such as diabetes, gastro-paresis, liver and kidney dysfunction, and cardiopulmonary insufficiency.
• Contraindications for metoclopramide or dexamethasone treatment.
• Taking opioids or drugs that affect gastric motility.
• A history of esophageal, gastric, or upper abdominal surgery.
• A need for immediate emergency surgery, resulting in insufficient study time (120 min).
• Inability of the patient or their family to understand the study protocol.

Sponsors & Collaborators

• Ahmed Nassar Ibrahim Mohammed: lead
• Assiut University: collaborator

MeSH Terms

Conditions

Accidental Injuries

Interventions

Dexamethasone; Metoclopramide

Condition Hierarchy (Ancestors)

Wounds and Injuries

Intervention Hierarchy (Ancestors)

Pregnadienetriols; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Steroids, Fluorinated; Benzamides; Amides; Organic Chemicals; para-Aminobenzoates; Aminobenzoates; Benzoates; Acids, Carbocyclic; Carboxylic Acids; Chlorobenzoates; Hydroxybenzoate Ethers; Hydroxybenzoates; Hydroxy Acids; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Phenyl Ethers; Phenols

Central Study Contacts

Ahmed Nassar, Student

CONTACT

00201014421973; amm7.nassar@gmail.com

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Resident doctor

Study Record Dates

• First Submitted: December 15, 2025
• First Posted: January 15, 2026
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): April 1, 2028
• Study Completion (Estimated): April 1, 2028
• Last Updated: January 15, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share