Could Computerized Tomography be an Alternative to Colonoscopies for Screening for Colorectal Cancer?

NCT07342998 | Active Not Recruiting

• 1 other identifier: E-10333602-050.04-339197
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this observational study is to investigate whether computed tomography can be used as an alternative to colonoscopy in colon cancer screening. The main question the study aims to answer is: Can colon cancer screening be performed as effectively with computed tomography as with colonoscopy? Participants in the colon cancer screening group will be divided into two groups: those who underwent colonoscopy and those who underwent computed tomography. The screening effectiveness of the two methods will be compared.

Conditions

Colo-rectal Cancer; Screening Colonscopy; Colon Cancer Screening

Keywords

colonscopy; colon cancer; cancer screening

Outcome Measures

Primary Outcomes (1)

• polyp/cancer incidance

  Number of patients with polyps and cancer detected by screening

  when the pathology results are available after a colonoscopy or when the report is written after a CT scan through study completion, an average of 2 years

Study Arms (2)

colonscopy

participant screened by colonoscopy

tomography

participant screened by tomography

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

CT scans and colonoscopies performed on patients aged 50-70 at Bilecik Research and Training Hospital between January 1, 2023, and December 31, 2024, will be examined.

You may qualify if:

• All participants aged 50-70 who have undergone colonoscopy screening
• All participants aged 50-70 who have undergone abdominal computed tomography

You may not qualify if:

• \- The patient has a history of colon cancer

Sponsors & Collaborators

• Bilecik Seyh Edebali Universitesi: lead

Study Sites (1)

Bilecik Seyh Edebali University

Bilecik, Bilecik, 11000, Turkey (Türkiye)

Location

Related Publications (2)

• Mang T, Graser A, Schima W, Maier A. CT colonography: techniques, indications, findings. Eur J Radiol. 2007 Mar;61(3):388-99. doi: 10.1016/j.ejrad.2006.11.019. Epub 2007 Jan 16.

  PMID: 17224254 RESULT

• Terasawa T, Tadano T, Abe K, Sasaki S, Hosono S, Katayama T, Hoshi K, Nakayama T, Hamashima C. Single-round performance of colorectal cancer screening programs: a network meta-analysis of randomized clinical trials. BMC Med. 2025 Feb 21;23(1):110. doi: 10.1186/s12916-025-03948-9.

  PMID: 39985068 RESULT

MeSH Terms

Conditions

Colonic Neoplasms

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 21, 2025
• First Posted: January 15, 2026
• Study Start: July 15, 2025
• Primary Completion: March 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: January 15, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)