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PANDA
Sponsor study identifier
interventional
60
1 country
2
Study Start
February 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
November 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The PANDA trial is studying whether two types of physical activity - a walking program and supervised karate training - are safe, acceptable, and possible for adults with certain personality disorders. The goal is to see if these activities can help people while being safe and easy to do. Who can take part:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 12, 2025
Actual (reported)January 14, 2026
Actual (reported)February 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
November 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Referral rate (initial interest rate)
The proportion of patients approached by clinical staff who agree to be referred to the research team for further information about the study. Calculation: Number of patients referred to the research team/Number of patients approached by clinical staff.
Assessed continuously throughout the recruitment period.
Screening rate
The proportion of participants referred by clinical staff who complete the research team's information session. Calculation: Number of participants attending the information session/Number of participants referred by clinical staff.
Assessed continuously throughout the recruitment period, prior to each participant's baseline assessment.
Recruitment rate (consent rate)
Participants in this arm receive treatment as usual and function as the control group.
Participants receive supervised karate training twice a week for 8 weeks from experienced instructors.
Participants follow an 8-week pedometer-based walking program with individually tailored goals.
The karate group will be offered an 8-week, group-based Shotokan Karate-Do program with two 1-hour sessions per week, delivered at a local karate club. Sessions will be led by two experienced instructors who has recieved lectures in relevant personality pathology and treatment principles. The instructors will plan and adapt the training, which includes meditation to promote focus and calm, Kihon (basic techniques) to practice fundamental movements, Kumite (partnered exercises) to develop coordination, collaboration, and controlled sparring skills, and stretching to support recovery and flexibility. Exercises will be tailored individually to participants' needs, addressing both physical and cognitive aspects of training. Participants will receive relevant equipment, such as a karate uniform and participants may continue attending classes after the 8-week intervention until the end of the study.
Mental Health Center Stolpegård, Copenhagen University Hospital -Mental Health Services CPH, Copenhagen Denmark
Gentofte Municipality, Capital Region, 2820, Denmark
Mental Health Centre Glostrup, Copenhagen University Hospital - Amager and Hvidovre, Denmark
Glostrup Municipality, Capital Region, 2620, Denmark
Petersen J, Palic S, Nyboe L, Schuster M, Videbech P, Midtgaard J. Physical activity in the management of borderline personality disorder: A scoping review. Psychiatry Res. 2025 Aug;350:116535. doi: 10.1016/j.psychres.2025.116535. Epub 2025 May 5.
Julie Midtgaard, Professor
Copenhagen University Hospital - Amager and Hvidovre
First Submitted
December 12, 2025
First Posted
January 14, 2026
Study Start
February 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
The proportion of participants who consent to join the trial after attending the research team's information session. Calculation: Number of participants providing informed consent/Number of participants attending the information session.
Assessed continuously throughout the recruitment period.
Retention rate
The proportion of participants who remain in the trial until completion. Calculation: Number of participants completing the study/Number of participants initially enrolled.
From each participant's baseline assessment (week 0) to their 12-week follow-up.
Adherence
The extent to which participants comply with their assigned intervention. Individual criteria: Karate group: Attendance at ≥8 of 16 sessions (≥50%). Walking group: Achievement of individually defined weekly step goals in ≥6 of 8 weeks (≈70%). Progression criterion: Progression to a full-scale RCT without modification requires that at least 70% of participants in each intervention arm meet these adherence criteria.
Assessed during the 8-week intervention period for each participant.
Safety (Adverse Events)
Occurrence of any adverse events (AEs) during the intervention period. Assessment: Bi-weekly self-reported electronic questionnaires via REDCap. Extraction from medical records for events such as emergency department visits.
Weeks 0-8 for the intervention period for each participant; medical record review extend through 12-week follow-up.
Reasons for non-participation or drop-out
Documented explanations provided voluntarily by participants who decline participation or discontinue the trial. Assessment: Categorized according to predefined options (e.g., intervention not attractive, inconvenient timing, travel distance, lack of energy, other).
Collected throughout recruitment and study participation for each individual (from invitation to 12-week follow-up).
Simple Physical Activity Questionnaire (SIMPAQ)
Baseline and 8-weeks follow-up.
Exercise Addiction Inventory (EAI)
Baseline, 8 weeks, and 12 weeks follow-up.
Body composition
Baseline and at 8-weeks follow-up.
Personality Disorder Severity Scale - ICD 11 (PDS ICD 11)
Baseline, 8 weeks, and 12 weeks follow up.
Inventory of Interpersonal Problems - 32 items (IIP 32)
Baseline, 8 weeks, and 12 weeks follow up.
The pedometer-based walking group include a pedometer (Garmin VivoFit 4) and a walking diary, inspired by NICE guidance (PH41). Materials will be reviewed with each participant to ensure understanding and support individual goal-setting. Goals will be tailored to each participant, aiming either to gradually increase daily PA or to establish a structured and manageable activity routine, depending on individual needs and preferences. The diary encourages daily step recording and reflection on physical activity habits. Throughout the 8-week intervention, participants will receive regular check-ins by phone or online at weeks 2, 4, and 6 to review progress, provide structured feedback, and adjust goals as needed.
Treatment as usual comprise treatment as usual within the psychiatric services. Participants are engaged in ongoing psychotherapeutic treatment when referred to the PANDA study, which includes group and/or individual therapy. As part of the group allocation information, they will be informed about the official Danish physical activity guidelines. Participants will be encouraged to continue their usual daily activities without any specific guidance toward or restriction from engaging in other interventions.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
November 1, 2026
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
February 3, 2026
Record last verified: 2026-02
Individual participant data cannot be shared publicly due to ethical constraints; however, qualified researchers may submit individual requests for access.
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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