The Effectiveness of Dialectical Behavioral Group Psychotherapy Compared to Supportive Individual Psychotherapy In Patients With Borderline Personality Disorder: A Study on Therapeutic Alliance, Depression, Cognitive Function, Impulsivity, Suicide Risk, BDNF Levels, NFkB Levels, SOD Levels

NCT07449104 | Completed DMC

• 2 other identifiers: 976/EC/KEPK-RSDK/2021247/UN7.5.4/HK/2022
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

In the context of therapy for Borderline Personality Disorder, our department had conduct a study titled "The Effectiveness of Dialectical Behavioral Group Psychotherapy Compared to Supportive Individual Psychotherapy in Patients with Borderline Personality Disorder: A Study of Therapeutic Alliance, Depression, Cognitive Function, Impulsivity, Suicide Risk, BDNF Levels, NFkB Levels, SOD Levels."

Conditions

Borderline Personality Disorder (BPD)

Keywords

Psychotherapy; DBT; therapeutic alliance; depression; cognitive function; impulsivity; suicide risk; BDNF; NFκB; SOD; BPD; Supportive psychotherapy

Outcome Measures

Primary Outcomes (5)

• Therapeutic Alliances with California Psychotherapy Alliance Scales (CALPAS)

  California Psychotherapy Alliance Scales (CALPAS) score. A higher CALPAS (California Psychotherapy Alliance Scale) score indicates a stronger, more positive therapeutic alliance between a patient and their therapist. The California Psychotherapy Alliance Scale (CALPAS) uses a 7-point Likert scale for its 24 items, ranging from 1 ("not at all") to 7 ("very much so"). Minimum score 24 and maximum score 168.

  13 weeks

• Depression with GRID Hamilton Depression Rating Scale (GRID HAM-D)

  GRID Hamilton Depression Rating Scale (GRID HAM-D) score, interval, higher total scores indicating greater severity of depression. Minimum Score: 0 (No depression) Maximum Score: 52 (Severe depression)

  13 weeks

• cognitive function with Montreal Cognitive Assesment versi Indonesia (MoCA-Ina)

  Montreal Cognitive Assesment Indonesian version (MoCA-Ina) score, interval. A 30-point screening tool validated to detect mild cognitive impairment (MCI) and dementia in Indonesia, with a score of 26 or higher considered normal.

  13 weeks

• impulsivity with Barrat Impulsiveness Scale (BIS11)

  Barrat Impulsiveness Scale (BIS11) score, interval, Higher scores indicate greater impulsivity, with 30-51 indicating low, 52-71 average, and 72+ high impulsivity.

  13 weeks

• Suicide Risk with Columbia Suicide Severity Rating Scale (CSSRS)

  Columbia Suicide Severity Rating Scale (CSSRS) score, interval, Any "Yes" answer to behavior or ideation requires further clinical assessment.

  13 weeks

Secondary Outcomes (3)

• NFkB Levels in ng/ml

  13 weeks

• BDNF level in pg/ml

  13 weeks

• SOD levels in ng/ml

  13 weeks

Study Arms (2)

DBT group psychotherapy

EXPERIMENTAL

13 weeks, one session per week. Each week, 2-hour dialectical therapy group session for 5 patients per group.

Behavioral: DBT group psychotherapy

Suportive psychotherapy

ACTIVE COMPARATOR

13 weeks, one session per week. Each week, one 30-minute session of individual supportive psychotherapy.

Behavioral: Supportive Psychotherapy

Interventions

DBT group psychotherapy BEHAVIORAL

13 weeks, one session per week. Each week, one 2-hour dialectical therapy group session for 5 patients in a group.

DBT group psychotherapy

Supportive Psychotherapy BEHAVIORAL

13 weeks, one session per week. Each week, one 30-minute session of individual supportive psychotherapy

Suportive psychotherapy

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Aged 18-60 years old
• Diagnosed with Borderline Personality Disorder based on the Structured Clinical Interview for DSM-V Axis II Disorders (SCID-II)
• Junior high school education or higher
• Patients willing to participate in the study.

You may not qualify if:

• Taking immunosuppressive drugs since one week before the study.
• Based on interviews or medical records, there is no history of post-stroke, epilepsy, or diabetes mellitus.

Sponsors & Collaborators

• Natalia Dewi Wardani, MD: lead
• Faculty of Medicine University of Diponegoro, Indonesia: collaborator

Study Sites (1)

Medical Faculty Diponegoro University

Semarang, Central Java, 50275, Indonesia

Location

Related Publications (1)

• MacDowell KS, Marsa MD, Buenache E, Villatoro JML, Moreno B, Leza JC, Carrasco JL. Inflammatory and antioxidant pathway dysfunction in borderline personality disorder. Psychiatry Res. 2020 Feb;284:112782. doi: 10.1016/j.psychres.2020.112782. Epub 2020 Jan 11.

  PMID: 31955054 BACKGROUND

Related Links

• ethics committee RSUP dr.Kariadi website

MeSH Terms

Conditions

Borderline Personality Disorder; Depression; Impulsive Behavior

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Study Officials

• M.I. Widiastuti MIW Widiastuti, Prof. dr.PAK(K), Sp.S(K), M.Sc

  Medical Faculty Diponegoro University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Each patient was assigned an identification number, and the researcher who drew blood did not know whether the patient was in the treatment group or the control group
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Head of Psychiatry Residency Study Program Medical Faculty, Diponegoro University. Principal Investigator

Model Details: Randomization was performed to assign the research sample to either the treatment group (Dialectical Behavior Therapy Group) or the control group (Supportive Individual Psychotherapy).

Study Record Dates

• First Submitted: February 21, 2026
• First Posted: March 4, 2026
• Study Start: December 16, 2021
• Primary Completion: December 16, 2022
• Study Completion: November 5, 2023
• Last Updated: March 6, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

ID (1)