Uterine Artery Doppler Indices and Uterocervical Angle Measurment in Prediction of Preterm Labor

NCT07336173 | Recruiting

• 1 other identifier: KFSIRB200-597
• Study Type: observational
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate the role of uterine artery doppler indices and uterocervical angle measurement in prediction of preterm labor .The main question it aims to answer is: Does combination of both uterine artery doppler indices and uterocervical angle measurement increase sensitivity and specificity for prediction of established preterm labor ? Participants already performing uterine artery doppler as part of their regular antenatal care .measurement of anterior uterocervical angle will be added between 24 to 34 weeks gestation to predict preterm labor in candidates .

Conditions

Preterm Labor

Outcome Measures

Primary Outcomes (1)

• Sensitivity, specificity and accuracy performance of uterine artery Doppler indices and uterocervical angle assed by ultrasound for prediction of preterm labor

  Its hypothesized that: Abnormal uterine artery Doppler indices and an abnormal (acute) uterocervical angle (\< 95°) are significant predictors of preterm labor. The combination of these two parameters will enhance the sensitivity and specificity of preterm labor prediction.

  From 24 to 34 weeks gestation

Interventions

Ultrasound DEVICE

Trans abdominal ultrasound will be used to measure uterine artery doppler indices Trans vaginal ultrasound will be used to measure anterior uterocervical angle

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: Only pregnant females
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Eligible participants will be recruited among those attending the antenatal clinic or Obstetrics Emergency Unite at Kafrelsheikh University Hospital.

You may qualify if:

• Patient who will give verbal \& written will informed consent.
• Pregnant women between 18 and 40 years old of age
• Singleton pregnancy
• Gestational age will be confirmed by first trimester ultrasound scan (\<14 weeks).
• Gestational age between 24 and 34 weeks .
• Threatened preterm labor which is defined as:
• Presence of at least one uterine contraction every 10 minutes lasting ≥30 seconds . Cervical dilatation ≤3 cm . Cervical effacement \<80%.

You may not qualify if:

• Obstetric:
• Ruptured membranes
• Clinical evidence of Chorioamnionitis.
• Fetal compromise on evaluation.
• Severe obstetric complications (e.g., severe Preeclampsia, Eclampsia).
• Diagnosed intrauterine growth restriction (IUGR).
• Congenital fetal anomalies.
• Multiple pregnancies.
• Prior cervical surgery (e.g., cone biopsy, cerclage).
• Non-Obstetric:
• Significant maternal medical disorders (e.g., chronic hypertension, diabetes mellitus, liver dysfunction).
• Severe non-obstetric complications (e.g., acute abdomen).

Sponsors & Collaborators

• Kafrelsheikh University: lead

Study Sites (1)

Kafr elsheikh university hospital

Kafr ash Shaykh, Egypt

RECRUITING

MeSH Terms

Conditions

Obstetric Labor, Premature

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

Nourhan M Shalaby, Master

CONTACT

+201060674910; nourashalaby44@gmail.com

Ahmed M Fathy, MD

CONTACT

+2 0122 1485021

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident physician doctor

Study Record Dates

• First Submitted: January 2, 2026
• First Posted: January 13, 2026
• Study Start: January 15, 2026
• Primary Completion: April 1, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: January 20, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)