Chair Exercise and Intergenerational Activities in Older Adults With Physio-Cognitive Decline Syndrome

NCT07335978 | Completed DMC

• 1 other identifier: 25-06-0948
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to investigate the effects of chair exercise followed by intergenerational activity in frailty syndrome and changes in serum mBDN levels among older adults with Physio-Cognitive Decline Syndrome (PCDS), as a novel approach integrating physical and social intervention with biomolecular assessments In older adults with PCDS

• Weeks 1-2: once weekly
• Weeks 3-6: twice weekly
• Week 7-12: three times weekly Additional activities include (intervention and control group):
• Weeks 1 and 11: teleconference session on nutrition and physical exercise supported by electronic flyers (e-flyers).
• Weeks 3, 5, 7, 11, and 13: distribution of e-flyers on elderly nutrition and the muscle-brain axis. Additional Activity (intervention group) \- Weeks 13-16: intergenerational activities at an orphanage with children aged \>5 years Assessments (intervention and control group):
• Week 1: serum mBDNF and HbA1c measurement
• Week 12 and 16: physical assessments (body weight, height, handgrip strength, gait speed, MoCA-Ina, and IADL) and serum mBDNF measurement. Control Group: The participant will receive general health education on performing physical exercise 1-3 times per week throughout week 1-16

Conditions

Cognitive Frailty

Outcome Measures

Primary Outcomes (2)

• Frailty Syndrome Status

  • Change in frailty syndrome status (assessed using Cardiovascular Health Study criteria: score 0 robust, 1-2 pre-frail, ≥3 frail) from baseline to week 16.

  From enrollment to the end of treatment at 12 weeks

• serum mature brain-derived neurotrophic factor (mBDNF)

  Change in serum mature brain-derived neurotrophic factor (mBDNF) levels (measured by ELISA) from baseline to week 16.

  from baseline to week 16

Secondary Outcomes (5)

• Hand grip strength

  from baseline to week 16

• Gait Speed Test

  baseline to week 16

• Cognitive Function

  from baseline to week 16

• health-related quality of life (SF-12 questionnaire)

  from baseline to week 16

• serum mBDNF levels

  baseline to week 16

Other Outcomes (7)

• Adherence to exercise sessions

  from baseline to week 12

• Intergenerational activities

  from weeks 13 to weeks 16

• Physical Activity Scale for the Elderly, PASE

  from baseline to week 16

Study Arms (2)

Intervention Arm

EXPERIMENTAL

Nutritional education + 12 weeks structured chair-based exercise (PEROSI protocol, progressive frequency from 1 to 3 sessions/week, 60 minutes/session, supervised online) followed sequentially by 4 weeks SHP-based intergenerational activities (8 sessions, 2x/week, 45 minutes/session, paired 1:1 elderly-child using AMIR educational materials at selected orphanages).

Behavioral: Intervention 1

Control Arm

NO INTERVENTION

Nutritional education only (2 personalized dietitian tele-conferences at weeks 1 and 11; 5 educational e-flyers at weeks 3, 5, 7, 13, and 15)

Interventions

Intervention 1 BEHAVIORAL

Nutritional education + 12 weeks structured chair-based exercise (PEROSI protocol, progressive frequency from 1 to 3 sessions/week, 60 minutes/session, supervised online) followed sequentially by 4 weeks SHP-based intergenerational activities (8 sessions, 2x/week, 45 minutes/session, paired 1:1 elderly-child using AMIR educational materials at selected orphanages).

Intervention Arm

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

* Aged 60-75 years * Meet diagnostic criteria for physio-cognitive decline syndrome (PCDS): gait speed \<1.0 m/s and/or hand grip strength \<28 kg (men) or \<18 kg (women), and MoCA-Ina score 22-26 * Instrumental Activities of Daily Living (IADL) score \>5 * Able to understand and follow instructions adequately * Willing to participate and provide written informed consent

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Atma Jaya Catholic University of Indonesia: lead

Study Sites (1)

Catholic Church of St. Anthony of Padua, Bidaracina, GKI Depok, Catholic Church of St. Anna, Catholic Chrusch St. Aloysius Gonzaga

Jakarta, Jakarta Special Capital Region, Indonesia

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Princial Investigator

Study Record Dates

• First Submitted: January 2, 2026
• First Posted: January 13, 2026
• Study Start: September 24, 2025
• Primary Completion: March 16, 2026
• Study Completion: March 16, 2026
• Last Updated: May 4, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

ID (1)