Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease

NCT07335692 | Recruiting

• 1 other identifier: 9691
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Lewy body disease (LBD) is a neurodegenerative disorder that causes cognitive and behavioral problems. However, it is difficult to diagnose, and its pathophysiology is still not fully understood. The usual diagnostic criteria for LBD have excellent specificity but poor sensitivity. In particular, we lack paraclinical tests that can make a significant contribution. LBD patients may exhibit abnormalities in brain activity dynamics, which can be detected by EEG and may be linked to neuronal dysfunctions specific to the disease. The objective of this study is twofold: first, to assess the validity of this observation, that is, to confirm that the observed phenomenon is indeed linked to the pathophysiology of LBD, and second, to clarify the nature of these abnormalities by exploring the brain dynamics of LBD patients in greater detail.

Conditions

Lewy Body Disease

Keywords

Lewy Body Disease; Neurodegenerative disorder

Outcome Measures

Primary Outcomes (1)

• Parameter θ of dynamic fluidity of brain activity

  Parameter θ of dynamic fluidity of brain activity (quantifying the system's ability to move away from its current configuration) θ is used to measure something specific in the brain: how flexible its activity is. Quantifying the system's ability to move away from its current configuration: * In plain words, θ tells us how much the brain can change from its current state. * High θ → brain is very flexible, can switch between states easily. * Low θ → brain is rigid, stays in the same pattern longer.

  Up to 12 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult subjects (≥18 years old) who participated in the Alpha-Lewy-MA cohort and underwent RT-QuIC analysis and underwent a standard EEG examination at HUS between January 1, 2012, and January 1, 2020.

You may qualify if:

• Adult subjects (≥18 years old).
• Subject who participated in the Alpha-Lewy-MA cohort and underwent RT-QuIC analysis.
• Subject who underwent a standard EEG examination at HUS between January 1, 2012, and January 1, 2020.

You may not qualify if:

• \- Subject who expressed opposition to participating in the study.

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service de psychiatrie de la personne âgée - CHU de Strasbourg - France

Strasbourg, 67091, France

RECRUITING

MeSH Terms

Conditions

Lewy Body Disease; Neurodegenerative Diseases

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Dementia; Movement Disorders; Synucleinopathies; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Ludovic DORMEGNY-JEANJEAN, MD

CONTACT

33 3 88 11 69 21; ludovic.jeanjean@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 2, 2026
• First Posted: January 13, 2026
• Study Start: June 2, 2025
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): June 2, 2026
• Last Updated: January 13, 2026

Record last verified: 2026-01

Locations

FR (1)