Study of Platelet Population Changes Under Circulatory Support With ECMO

NCT07334457 | Recruiting

• 1 other identifier: 9614
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Advances in flow cytometry techniques have led to a better understanding of platelet phenotypes and have revealed the existence of four major platelet populations with distinct functional properties (native, proaggregating, procoagulating, or apoptotic). These phenotypes have a significant impact on the hemostatic capacity of blood platelets, and a proportional change in these populations during ECMO treatment could, at least in part, contribute to the observed complications.

Conditions

Cardiac Failure; Respiratory Failure

Keywords

Cardiac Failure; Respiratory Failure

Outcome Measures

Primary Outcomes (1)

• Proportional Changes in the Different Platelet Populations (native, proaggregating, procoagulant, or apoptotic)

  Proportional Changes in the Different Platelet Populations (native, proaggregating, procoagulant, or apoptotic) on Days 1, 3, and 7 after the initiation of ECMO treatment.

  Days 1, 3, and 7 after the initiation of ECMO treatment.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

\- Adult patient (≥18 years) treated in one of the intensive care units of the Anesthesia and Intensive Care Department at Strasbourg University Hospital and implanted with veno-arterial or veno-venous ECMO within the previous 24 hours.

You may qualify if:

• Adult patient (≥18 years) treated in one of the intensive care units of the Anesthesia and Intensive Care Department at Strasbourg University Hospital.
• Implanted with veno-arterial or veno-venous ECMO within the previous 24 hours.

You may not qualify if:

• Subject who has expressed their opposition to participating in the study.
• Subject under legal protection.
• Subject under guardianship or curatorship.

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service d'anesthésie-réanimation - CHU de Strasbourg - France

Strasbourg, 67091, France

RECRUITING

MeSH Terms

Conditions

Heart Failure; Respiratory Insufficiency

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Respiration Disorders; Respiratory Tract Diseases

Central Study Contacts

Charles TACQUARD, MD, PhD

CONTACT

33.3.69.55.16.08; charlesambroise.tacquard@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 30, 2025
• First Posted: January 12, 2026
• Study Start: March 11, 2025
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): March 11, 2027
• Last Updated: January 12, 2026

Record last verified: 2025-12

Locations

FR (1)