MRI-Based Estimation of Lumbar CSF Volume and Its Clinical Impact on Spinal Anaesthesia

NCT07333703 | Completed

• 1 other identifier: SUKAEK-2022/1/14
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to investigate the clinical impact of lumbar cerebrospinal fluid (CSF) volume on spinal anesthesia characteristics. A total of 40 adult patients, aged 18 to 75 years and classified as ASA physical status I-III, who had undergone 3D T2-weighted lumbosacral MRI within the past six months, were enrolled. Intrathecal anesthesia was administered with 4 mL (20 mg) of 0.5% hyperbaric bupivacaine via the L3-L4 interspace in a sitting position. CSF volume was measured from the lower half of the L1 vertebral body to the sacral end using the volume of interest (VOI) method on sagittal 3D T2-weighted MR images, processed with the ITK-SNAP software. Primary outcome was the correlation between lumbosacral CSF volume and peak sensory block level. Secondary outcomes included correlations with the onset time and duration of sensory and motor block, two-segment regression time, and patient characteristics such as height, weight, BMI, and age.

Conditions

Spinal Anaesthesia; Magnetic Resonance Imaging (MRI); Lumbosacral Spinal Stenosis; Anaesthesia

Keywords

Spinal Anaesthesia; Peak sensory block level; Lumbosacral volume; MRI

Outcome Measures

Primary Outcomes (1)

• The primary outcome was to assess the correlation between lumbosacral CSF volume and peak sensory block level.

  From enrollment to the end of study 33 months

Interventions

Distribution of spinal anesthetic agent PROCEDURE

Under aseptic conditions and in a sitting position, a 25G spinal needle was inserted through the midline at the L₃-L₄ intervertebral space, advancing parallel to the dura fibers. Upon clear cerebrospinal fluid (CSF) flow, the needle bevel was oriented cephalad and 20 mg of 0.5% hyperbaric bupivacaine was injected into the intrathecal space. Patients were kept supine for 5 minutes before sensory block was assessed by pinprick test from the midclavicular line. All spinal anesthesia procedures were performed by the same experienced anesthesiologist.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged between 18 and 75 years, classified as ASA physical status I-III, who had undergone 1.5 Tesla lumbosacral MRI within the last six months.

You may qualify if:

• Aged 18-75 years
• ASA physical status I-III
• Who had undergone 1.5 Tesla lumbosacral MRI within the last six months

You may not qualify if:

• The presence of neurological diseases and allergy to local anesthetics
• Refusal to undergo spinal anesthesia
• Contraindications for spinal anesthesia
• Local infection at the lumbar site

Sponsors & Collaborators

• Samsun University: lead

Study Sites (1)

Samsun University

Samsun, Turkey (Türkiye)

Location

Related Publications (1)

• Stienstra R, Greene NM. Factors affecting the subarachnoid spread of local anesthetic solutions. Reg Anesth. 1991 Jan-Feb;16(1):1-6. No abstract available.

  PMID: 2007097 RESULT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 21, 2025
• First Posted: January 12, 2026
• Study Start: February 1, 2023
• Primary Completion: September 1, 2025
• Study Completion: November 15, 2025
• Last Updated: January 12, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)