Efficacy of Interactive Audio-based Mindfulness ChatGPT-Powered Intervention on Well-being

NCT07333365 | Recruiting

• 1 other identifier: IRB-25-212-A172-M2(1125)
• Study Type: interventional
• Target: 210
• Locations: 1 country
• Sites: 1

Brief Summary

Brief mindfulness intervention is a short form is a form of short-duration practice, typically delivered for around 30 minutes or less (Howarth et al., 2019). It can be conducted in various formats, including a short breathing exercise or body scan (Palascha et al., 2021), and are increasingly offered through digital platforms, including app-based formats. Empirical evidence has examined the efficacy of brief mindfulness intervention and yielded mixed results. For some studies, positive effects were found, while some studies found no supporting evidence. Such inconsistencies may be due to the several current limitations of brief mindfulness intervention. Firstly, the duration of the intervention is too short. Given this brevity, these short practices may not offer the same immersion and depth that traditional mindfulness may offer. Secondly, most brief mindfulness utilised audio-based formats, which tend to be passive in nature and may not fully engage participants. Lastly, for brief mindfulness delivered through app-based platforms, these applications adopt a self-help approach, which may lower engagement and user commitment. Moreover, these applications also relied on audio guides which lacks the student-facilitator engagement found in traditional classes. To address the current limitations within the literature, a between-within-subjects experiment will be conducted where participants will be randomly assigned to one of the three conditions: (1) an interactive brief mindfulness breathing ChatGPT-powered intervention, (2) an interactive mind-wandering ChatGPT-powered control, or (3) a mindfulness breathing audio control. We hypothesise that the brief mindfulness breathing ChatGPT-powered intervention group will have significant improvements in well-being outcomes as compared to the other two control groups. By exploring the potential of an interactive ChatGPT-powered intervention, this study aims to understand its efficacy in improving well-being.

Conditions

Perceived Stress; Positive and Negative Affect; State Anxiety; Self Control; State Mindfulness Attention

Outcome Measures

Primary Outcomes (5)

• Stress

  Participants' current stress levels will be measured with a single item ("How stressed do you feel right now?"), rated on an 11-point scale (0 = No stress, 10 = Extreme stress).

  Change from pre-intervention (baseline, before intervention) to immediately post-intervention (after the 15-minute session)

• Positive and Negative Affect

  Participants' affective states will be measured using the 18-item Circumplex Model of Affect Scale (Russell, 1980), which assesses emotional states across two separate dimensions: positive affect (PA) and negative affect (NA). Participants are required to indicate the extent to which they currently experience each emotion on a 5-point Likert scale (1 = Not at all, 5 = Extremely), in response to the question, "Overall, how do you feel right now?".

  Change from pre-intervention (baseline) to immediately post-intervention (after the 15-minute session)

• State Anxiety

  Participants' state anxiety levels will be measured with the 6-item Spielberger State-Trait Anxiety Inventory (STAI; Marteau \& Bekker, 1992), rated on a 4-point Likert scale (1 = Not at all, 4 = Very much). Participants are required to rate how they generally feel in response to statements presented (e.g., "I feel calm", "I am tense", "I feel upset").

  Change from pre-intervention (baseline) to immediately post-intervention (after the 15-minute session).

• Self-control Capacity

  Participants' self-control capacity will be measured with the 5-item Brief State Self-Control Capacity Scale (SMS-5; Ciarocco et al., 2009; Linder et al., 2015), rated on a 7-point Likert scale (1 = Very untrue of me, 7 = Very true of me). Participants are required to rate how they feel in response to the statements presented (e.g., "I feel drained now", "I feel lazy now", "I feel like my willpower is gone now").

  Change from pre-intervention (baseline) to immediately post-intervention (after the 15-minute session).

• State Mindfulness Attention

  Mindful Attention State. Participants' state mindfulness attention levels will be measured with the 21-item State Mindfulness Scale (SMS; Tanya \& Bernstein, 2013; Ruimi et al., 2022), on a 5-point Likert scale (1 = Not at all, 5 = Very well). Participants are required to rate how they feel in response to the statements presented (e.g., "I was aware of different emotions that arose in me", "I noticed many small details of my experience", "I felt that I was experiencing the present moment fully").

  Change from pre-intervention (baseline) to immediately post-intervention (after the 15-minute session).

Study Arms (3)

Interactive Mind Wandering (ChatGPT)

ACTIVE COMPARATOR

The intervention is a ChatGPT-powered mind wandering bot configured using a 15-minute guided exercise adapted from Hafenbrack et al. (2014), Clinton et al. (2018), and Arch and Craske (2006). The session is divided into one-minute segments: the first minute provides settling instructions (for example, inviting participants to adopt a comfortable position), followed by step-by-step guidance of the mindfulness breathing exercise. To foster reflection and encourage active engagement, the chatbot was trained to interact with the participants using interactive prompts. This includes asking questions, such as "When you are ready, please share...What feeling or memory stood out most clearly as your mind wandered?", "When you are ready, please share...where did your attention drift... to just now?".

Other: Interactive Mind Wandering ChatGPT-Powered Intervention

Interactive Mindfulness Breathing (ChatGPT)

EXPERIMENTAL

The intervention is a ChatGPT-powered mindfulness breathing bot configured using a 15-minute guided exercise adapted from Hafenbrack et al. (2014), Clinton et al. (2018), and Arch and Craske (2006). The session is divided into one-minute segments: the first minute provides settling instructions (for example, inviting participants to adopt a comfortable position), followed by step-by-step guidance of the mindfulness breathing exercise. To foster reflection and encourage active engagement, the chatbot was trained to interact with the participants using interactive prompts. This includes asking questions, such as " Share what this present moments feel like for you", "What sensations do you notice in your abdomen as you place your hand there?", "Share what stood out to you as you noticed your thoughts, feelings, or sensations just now.".

Other: Interactive Mindfulness Breathing ChatGPT-Powered Intervention

Mindfulness Breathing Audio

ACTIVE COMPARATOR

This intervention consists of listening to a 15-minute mindfulness breathing audio-only exercise, adapted from Hafenbrack et al. (2014), Clinton et al. (2018), and Arch and Craske (2006). There will be no verbal interactions in this intervention.

Other: Mindfulness Breathing Audio-only

Interventions

Interactive Mindfulness Breathing ChatGPT-Powered Intervention OTHER

The intervention is a ChatGPT-powered mindfulness breathing bot configured using a 15-minute guided exercise adapted from Hafenbrack et al. (2014), Clinton et al. (2018), and Arch and Craske (2006). The session is divided into one-minute segments: the first minute provides settling instructions (for example, inviting participants to adopt a comfortable position), followed by step-by-step guidance of the mindfulness breathing exercise. To foster reflection and encourage active engagement, the chatbot was trained to interact with the participants using interactive prompts. This includes asking questions, such as " Share what this present moments feel like for you", "What sensations do you notice in your abdomen as you place your hand there?", "Share what stood out to you as you noticed your thoughts, feelings, or sensations just now.".

Interactive Mindfulness Breathing (ChatGPT)

Interactive Mind Wandering ChatGPT-Powered Intervention OTHER

The intervention is a ChatGPT-powered mind wandering bot configured using a 15-minute guided exercise adapted from Hafenbrack et al. (2014), Clinton et al. (2018), and Arch and Craske (2006). The session is divided into one-minute segments: the first minute provides settling instructions (for example, inviting participants to adopt a comfortable position), followed by step-by-step guidance of the mindfulness breathing exercise. To foster reflection and encourage active engagement, the chatbot was trained to interact with the participants using interactive prompts. This includes asking questions, such as "When you are ready, please share...What feeling or memory stood out most clearly as your mind wandered?", "When you are ready, please share...where did your attention drift... to just now?".

Interactive Mind Wandering (ChatGPT)

Mindfulness Breathing Audio-only OTHER

This intervention consists of listening to a 15-minute mindfulness breathing audio-only exercise, adapted from Hafenbrack et al. (2014), Clinton et al. (2018), and Arch and Craske (2006). There will be no verbal interactions in this intervention.

Mindfulness Breathing Audio

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants who are aged 18 to 30 (inclusive)

You may not qualify if:

• Not applicable

Sponsors & Collaborators

• Nanyang Technological University: collaborator
• Singapore Management University: lead

Study Sites (1)

Singapore Management University

Singapore, Singapore

RECRUITING

MeSH Terms

Conditions

Anxiety Disorders; Self-Control

Condition Hierarchy (Ancestors)

Mental Disorders; Social Behavior; Behavior

Central Study Contacts

Xun Ci Soh

CONTACT

+65 83994980; xunci.soh.2024@msps.smu.edu.sg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master of Philosophy in Psychology Student

Study Record Dates

• First Submitted: December 3, 2025
• First Posted: January 12, 2026
• Study Start: October 30, 2025
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: January 12, 2026

Record last verified: 2025-10

Locations

SG (1)