Uterine Artery Doppler Flow Velocimetry Parameters for Predicting the Occurrence of Persistent Gestational Trophoblastic Neoplasia After Evacuation of Complete Hydatiform Mole

NCT07333326 | Not Yet Recruiting DMC

• 1 other identifier: UD-GTN-2025-1
• Study Type: observational
• Target: 175
• Locations: 0 countries
• Sites: N/A

Brief Summary

This Prospective study will be conducted To copare uterine blood flow using Doppler ultrasound before and after evacuation of hydatiform mole between female patients with remissions and those with development of post-molar persistent gestational trophoblastic neoplasia to detect accuracy,efficacy,predictive value and acceptability of uterine artery doppler in predicting gestional trophoblastic neoplasia .

Conditions

Gestational Trophoblastic Neoplasia; Complete Hydatiform Mole

Keywords

Gestational trophoblastic neoplasia

Outcome Measures

Primary Outcomes (1)

• Uterine artery Doppler flow velocimetry

  First the patient will evaluate the urinary bladder Positioning of patient:supine position Amidsagittal section of uterus and cervical canal is obtained and the transducer is moved laterally untill the paracervical vessels are visualized color flow doppler is applied the uterine arteriesare seen as aliasing vessels along the side of the cervix Uterine artery doppler indices will be measured PSV=peak systolic velocity EDV=end diastolic velocity TAMV=time average medium velocity P.I(pulsatile index)=PSV-EDV/TAMV R.I(resistance index)=(PSV-EDV)/PSV SD(systolic diastolic ratio)=PSV/EDF

  We will perform DFV of uterine arteries on both sides at admission and 4 - 6 weeks after evacuation.

Eligibility Criteria

• Age: 18 Years - 45 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Female 18:45 years with complete hydatiform mole

You may qualify if:

• Patients with confirmed diagnosis of complete hydatiform mole.
• Hemodynamically stable patient .
• No contraindication for anesthetic materials used for the evacuation .
• Acceptance of possible prolonged follow up , repeated uterine artery doppler ultrasound ,repeated HCG tests

You may not qualify if:

• Patient refusal to participate in the study.
• Patient with incomplete hydatiform mole .
• Patients who were lost during the follow-up period after this procedure.
• Contraindication for anesthetic materials used for the evacuation .

Sponsors & Collaborators

• Minia University: lead

MeSH Terms

Conditions

Gestational Trophoblastic Disease

Condition Hierarchy (Ancestors)

Trophoblastic Neoplasms; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Pregnancy Complications, Neoplastic; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Montaser Ismail Mahmoud, Assistant lecturer

  Minia University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mohamed Tawfiek Gad el Rab, Professor

CONTACT

+201061174636; mohammedtawfiek@gmail.com

Momen Mohamed Hassan, Professor

CONTACT

+201015224982; montaserismail15@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: December 17, 2025
• First Posted: January 12, 2026
• Study Start: January 10, 2026
• Primary Completion (Estimated): January 10, 2027
• Study Completion (Estimated): February 10, 2027
• Last Updated: January 12, 2026

Record last verified: 2025-12