BIOPHF
Blood Biomarkers Combined With Imaging Parameters for Prognostic Assessment in Patients With Different Types of Heart Failure: A Retrospective Single-Center Cohort Study
Sponsor study identifier
Secondary identifiers
OTHER · Xinjiang Medical University
observational
4,000
0 countries
N/A
Study Start
January 1, 2012
Actual (reported)Primary Completion
December 31, 2024
Actual (reported)Study Completion
January 31, 2025
Actual (reported)This study aims to develop a better model to predict one-year risk of death in patients with heart failure. We will test whether combining information from routine blood tests (like NT-proBNP) and heart scans (measuring features like epicardial fat density) improves risk prediction compared to using either type of data alone. This is a retrospective study using existing medical records of patients treated for chronic heart failure at Xinjiang Medical University First Affiliated Hospital between 2012 and 2024. No new patient contact or interventions are involved. The goal is to enable more accurate, personalized risk assessment across different types of heart failure (HFrEF, HFmrEF, HFpEF).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 31, 2025
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2012
Actual (reported)December 31, 2024
Actual (reported)January 31, 2025
Actual (reported)December 28, 2025
Actual (reported)January 12, 2026
Actual (reported)All-cause mortality
Occurrence of death from any cause within one year (365 days) from the index date. The index date is defined as the date of the first qualifying encounter that meets all inclusion criteria.
1 year
Phenotype-specific prognostic performance
1 year
Independent prognostic value of EAT density in HFpEF
1 year
Adult patients (≥18 years) with a confirmed diagnosis of chronic heart failure who had both qualifying blood biomarker assessment and cardiac imaging performed within a specified window at the study center between 2012 and 2024. This is an observational cohort. No specific intervention is administered or withheld as part of the research protocol.
Adults diagnosed with chronic heart failure at the study center between 2012 and 2024.
Xiang Xie, PhD
First Affiliated Hospital of Xinjiang Medical University
4,000 participants (actual enrollment reported by the registry).
First Submitted
December 28, 2025
First Posted
January 12, 2026
Study Start
January 1, 2012
Actual (reported)Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction
Occurrence of HFimpEF
Through study completion,up to 13 years.
Association between baseline NT-proBNP level and HFimpEF
Through study completion, up to 13 years.
Association between baseline EAT density and HFimpEF
Through study completion, up to 13 years.
Contact the study team to confirm eligibility.
Primary Completion
December 31, 2024
Actual (reported)Study Completion
January 31, 2025
Actual (reported)Last Updated
January 27, 2026
Record last verified: 2026-01
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Source: ClinicalTrials.gov.
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