NCT07330518

Brief Summary

This randomised control trial will compare the efficacy of conventional buccal nerve block versus buccal trunk block using visual analogue scale to evaluate pain and additional anesthesia injection during extraction of mandibular molars.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
8mo left

Started Mar 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress17%
Mar 2026Jan 2027

First Submitted

Initial submission to the registry

December 8, 2025

Completed
1 month until next milestone

First Posted

Study publicly available on registry

January 9, 2026

Completed
2 months until next milestone

Study Start

First participant enrolled

March 20, 2026

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2027

Last Updated

February 4, 2026

Status Verified

December 1, 2025

Enrollment Period

10 months

First QC Date

December 8, 2025

Last Update Submit

February 1, 2026

Conditions

Keywords

Buccal Trunk Block

Outcome Measures

Primary Outcomes (2)

  • Intraoperative pain perception

    It was assessed while giving injection and during extraction of the tooth using the visual analog scale (VAS) scores. Facial pain scale uses facial expression to evaluate the amount of pain. It has scores ranging from 0 to 10 with 0 as the least pain and 10 as the worst pain. Score of more than 4 will be labelled as positive pain perception.

    Within 2hours of anesthesia administration

  • Need for supplemental infiltration

    Use of more than 1 anesthesia cartridges during procedure will be labelled as need for supplemental infiltration.

    Within 2 hour of initial anesthesia administration

Study Arms (2)

Conventional Buccal Nerve Block for anesthesia of buccal mucosa

EXPERIMENTAL

Administration of anesthesia using conventional buccal nerve block technique for anesthesia of buccal mucosa.

Procedure: Conventional Buccal Nerve Block

Buccal Nerve Trunk Block

EXPERIMENTAL

Administration of anesthesia at the buccal trunk 10mm above the coventional buccal nerve block for anesthesia of buccal mucosa.

Procedure: Buccal Nerve Trunk Block

Interventions

Arm Description: Administration of anesthesia at the level of occlusion lateral to last mandibular molar. Needle is inserted until bone contact is achieved. 1ml lidocaine with 1:100000 anesthesia is administered.

Conventional Buccal Nerve Block for anesthesia of buccal mucosa

Arm Description: Administration of anesthesia 10 mm above occlusal plane lateral to last mandibular molar. 1ml lidocaine with 1:100000 anesthesia is administered.

Buccal Nerve Trunk Block

Eligibility Criteria

Age20 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patients aged 20 to 60 years
  • Patients of both gender
  • Patient requiring extraction of mandibular molars

You may not qualify if:

  • Pregnant women
  • Pathologies associated with teeth i.e. cysts, tumors
  • Patients on radiotherapy or chemotherapy
  • Patients with mandibular fracture

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Watim Medical College & Dental Hospital

Islamabad, Islamabad, Pakistan, 46500, Pakistan

RECRUITING

Related Publications (1)

  • 1.Risbaf-Fakoor S, Hashemzehi H, Jahantigh H, Arab K, Gholami L. Adjunctive low-level laser therapy using 980-nm diode laser after impacted mandibular third molar surgery: a randomized clinical trial. Avicenna J Clin Med. 2020; 26 (4):199-205. 2.Mahat A, Yadav R, Yadav A, Acharya P, Dongol A, Sagtani A et al. A comparative study of the effect of sutureless versus multiple sutures technique on complications following third molar surgery in Nepalese subpopulation. Int J Dent. 2020; 2020(1):1-6. 3.Sruthi MA, Ramakrishnan M. Transpapillary injection technique as a substitute for palatal infiltration: a split-mouth randomized clinical trial. Int J Clin Pediatr Dent. 2021; 14(5):640-3. 4.Decloux D, Ouanounou A. Local anaesthesia in dentistry: a review. Int Dent J. 2020; 71(2):87-95. 5.Wang YH, Wang DR, Liu JY, Pan J. Local anesthesia in oral and maxillofacial surgery: A review of current opinion. J Dent Sci. 2021; 16(4):1055-65. 6.Koyata T, Yanai C, Shionoya Y, Takasugi Y, Sunada K. Buccal nerve trunk block anesthetizes the buccal mucosa beyond the papilla of the parotid duct. J Oral Maxillofac Surg. 2023;81(3):272-9. 7.Figueiredo R, Sofos S, Soriano-Pons E, Camps-Font O, Sanmarti-Garcia G, Gay-Escoda C, Valmaseda-Castellón E. Is it possible to extract lower third molars with infiltration anaesthesia techniques using articaine? A double-blind randomized clinical trial. Acta Odontol. Scand. 2021 Jan 2;79(1):1-8.

    BACKGROUND

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Central Study Contacts

Syed Saad Aftab Mohiuddin

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

December 8, 2025

First Posted

January 9, 2026

Study Start

March 20, 2026

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

January 1, 2027

Last Updated

February 4, 2026

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will not share

Locations