Distolingual Infiltration Verses Conventional Nerve Block in Mandibular Third Molar Extraction

NCT07296926 | Recruiting

• 1 other identifier: DSG-2023-335-4631-A
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial will compare the effectiveness of adding distolingual infiltration to conventional inferior alveolar and buccal nerve blocks for mandibular third molar extraction. A total of 120 patients will be allocated into two groups. Pain during flap elevation and bone guttering will be assessed using the Visual Analogue Scale.

Conditions

Pain (Visceral, Somatic, or Neuropathic)

Outcome Measures

Primary Outcomes (2)

• Pain during mucoperiosteal flap elevation

  Pain intensity experienced during flap elevation will be assessed using the Visual Analogue Scale (VAS). This is a 0-10 point numerical scale where participants indicate the pain level experienced at the time of flap elevation. Measurement Tool: Visual Analogue Scale (VAS) Scale: * Minimum score: 0 (no pain) * Maximum score: 10 (worst possible pain) * Directionality: Higher scores indicate worse pain

  During mucoperiosteal flap elevation on the day of surgery

• Pain During Bone Guttering

  Pain intensity during bone guttering will be recorded using the Visual Analogue Scale (VAS). Measurement Tool: Visual Analogue Scale (VAS) Scale: * Minimum: 0 (no pain) * Maximum: 10 (worst pain) * Higher scores = worse pain

  During bone guttering on the day of surgery.

Study Arms (2)

conventional nerve block injection

ACTIVE COMPARATOR

Inferior alveolar and buccal nerve block using 2% lignocaine with adrenaline (1:80,000) without distolingual infiltration.

Procedure: Conventional Inferior Alveolar and Buccal Nerve Block

conventional inferior alveolar with distolingual infilterate injection

EXPERIMENTAL

Inferior alveolar supplemented with distolingual infiltration using 2% lignocaine with adrenaline (1:80,000).

Procedure: Distolingual Infiltration plus Conventional Nerve Block

Interventions

Conventional Inferior Alveolar and Buccal Nerve Block PROCEDURE

Standard inferior alveolar and long buccal nerve block for mandibular third molar extraction.

conventional nerve block injection

Distolingual Infiltration plus Conventional Nerve Block PROCEDURE

Distolingual infiltration (0.2 ml) administered in addition to conventional inferior alveolar during mandibular third molar extraction.

conventional inferior alveolar with distolingual infilterate injection

Eligibility Criteria

• Age: 18 Years - 45 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy individuals
• Male and female
• Age 18-45 years
• Mandibular third molar impaction - all positions
• Mandibular third molar impaction - all classes

You may not qualify if:

• ASA status III and above
• Patients requiring multiple extractions in the same appointment
• Allergy to lignocaine
• Patients in whom adrenaline is contraindicated
• Medically compromised individuals e.g. poorly controlled diabetes, hypertension

Sponsors & Collaborators

• Watim Medical & Dental College: lead

Study Sites (1)

Dr Aimen Zafar

Islamabad, Pakistan

RECRUITING

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

dr aimen zafar Aimen zafar, bds

CONTACT

+923361056720; aimenali216@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: prinicpal investigator

Study Record Dates

• First Submitted: November 26, 2025
• First Posted: December 22, 2025
• Study Start: August 15, 2024
• Primary Completion: February 15, 2026
• Study Completion: April 15, 2026
• Last Updated: January 6, 2026

Record last verified: 2025-12

Locations

PA (1)