Effectiveness of a Large Language Model-Based Educational Tool on Visual Field Test Reliability in Glaucoma Patients

NCT07327242 | Enrolling By Invitation

• 1 other identifier: 82165
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate whether a large language model (LLM)-based audiovisual educational tool improves the test time and reliability of standard automated perimetry (SAP) using the SITA Standard 24-2 protocol in English-speaking glaucoma patients. Glaucoma is a disease that can lead to blindness if not properly monitored and treated. One of the most important tests for glaucoma is the visual field (VF) test, which checks how well a person can see in different directions. However, this test is difficult for many patients to perform correctly, especially if they don't fully understand how it works. Unreliable test results can lead to repeated visits, wasted time, and incorrect treatment decisions. This study is testing whether a computer-based educational tool, powered by artificial intelligence (AI), can help patients better understand the VF test before taking it. The study team want to see if this helps make the test results more reliable. The goal is to improve the quality of care while reducing the burden on patients and clinic staff. The LLMs will be used as an educational tool only, not for the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of disease.

Conditions

Glaucoma; Eye Disorders; Visual Fields; Visual Field Tests

Keywords

HVF; humphrey visual field test; Glaucoma; LLM; AI; GPT; ChatGPT; Education

Outcome Measures

Primary Outcomes (1)

• Humphrey Visual Field Test Taking Duration

  Test duration of Humphrey visual field test of the first tested eye will be compared to the same first tested eye of the study participant's previous test as a continuous variable.

  Same Day of Enrollment up to 2 hours

Secondary Outcomes (5)

• Changes in False Positives and False Negatives (Reliability Indices)

  Same Day of Enrollment up to 2 hours

• Proportion of Visual Field Test Standard Reliability

  Same Day of Enrollment up to 2 hours

• Patient satisfaction scale score as measured by Client Satisfaction Questionnaire-8 (CSQ-8)

  Same Day of Enrollment up to 2 hours

• Scores on the brief post-education knowledge assessment

  Same day of enrollment up to 2 hours

• Second-tested eyes

  Same Day of enrollment up to 2 hours

Study Arms (2)

Standard of Care

NO INTERVENTION

Patients will be informed of the standard protocol of Humphrey visual field testing by visual field technicians prior to their testing. Their education and knowledge will primarily come from the technicians themselves.

LLM-based Education + Standard of Care

EXPERIMENTAL

Participants will receive audiovisual education powered by a large language model (LLM) before their visual field test, in addition to the standard of care information provided by the Humphrey visual field technicians.

Other: LLM-based Education

Interventions

LLM-based Education OTHER

Participants will receive audiovisual education powered by a large language model (LLM) before their visual field test. The LLM will be presented using a 10 inch tablet or laptop device by a trained research team member. The interaction is intended to be self-guided, with no interference from the staff unless the LLM displays incorrect or "hallucinated" content. In such cases, the research staff will immediately correct any misinformation and record the occurrence, including details and frequency of the hallucination, for quality monitoring. The LLM module will deliver instructions, simulate the visual field test experience, and include a brief knowledge check. This LLM-based education is for research purposes only. Afterward, participants will proceed to their scheduled visual field test, which will include standard support from the clinic perimetrist.

LLM-based Education + Standard of Care

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults (≥18 years) with a diagnosis or suspected diagnosis of glaucoma
• English-speaking
• Scheduled for Humphrey visual field testing 24-2 SITA standard
• Having at least 2 prior visual field tests , with the most recent prior test performed using the 24-2 SITA Standard strategy within 2 years before enrollment.
• Best corrected visual acuity in both eyes ≥ 20/40

You may not qualify if:

• Unable to comply with study and questionnaires
• Participant has, in the opinion of the investigator, any physical or mental condition that would affect the participation in the study or may interfere with the study procedures, evaluations and outcome assessments.

Sponsors & Collaborators

• Stanford University: lead

Study Sites (1)

Byers Eye Institute

Palo Alto, California, 94303, United States

Location

MeSH Terms

Conditions

Glaucoma; Eye Diseases

Condition Hierarchy (Ancestors)

Ocular Hypertension

Study Officials

• Robert T Chang, MD

  Stanford University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: CARE PROVIDER
• Masking Details: The research personnel consenting and enrolling potential study participants and the visual field testing technicians will be blinded to the next study group the potential study participant will be put in.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Ophthalmology

Model Details: * Intervention Group: Participants will receive audiovisual education powered by a large language model (LLM) before their visual field test. The LLM will be presented using a 10 inch tablet or laptop device by a trained research team member. The interaction is intended to be self-guided, with no interference from the staff unless the LLM displays incorrect or "hallucinated" content. In such cases, the research staff will immediately correct any misinformation and record the occurrence, including details and frequency of the hallucination, for quality monitoring. The LLM module will deliver instructions, simulate the visual field test experience, and include a brief knowledge check. This LLM-based education is for research purposes only. Afterward, participants will proceed to their scheduled visual field test, which will include standard support from the clinic perimetrist. * Control Group: Participants will receive standard-of-care perimetrist instructions only

Study Record Dates

• First Submitted: December 5, 2025
• First Posted: January 8, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: January 8, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)