Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL

NCT07326670 | Recruiting

• 1 other identifier: PCNL-ANES-INFLAM-2025
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study aims to compare the effects of spinal and general anesthesia on perioperative systemic inflammatory response in patients undergoing percutaneous nephrolithotomy (PCNL). Systemic inflammatory indices derived from routine complete blood count parameters, including Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW), will be evaluated. Preoperative and postoperative laboratory values will be analyzed to determine whether the type of anesthesia influences systemic inflammatory markers and related clinical outcomes.

Conditions

Anesthesia Techniques; Percutaneous Nephrolithotomy; Systemic Inflammation

Keywords

Percutaneous nephrolithotomy; Spinal anesthesia; Neutrophil-to-lymphocyte ratio; Red cell distribution width; Systemic inflammation

Outcome Measures

Primary Outcomes (1)

• Perioperative change in systemic inflammatory indices (SII, SIRI, AISI, NLR, RDW)

  Changes in Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW) will be evaluated using routine complete blood count parameters obtained preoperatively and postoperatively.

  From preoperative period (within 6 hours before surgery) to postoperative period (6-24 hours after surgery)

Study Arms (2)

Spinal Anesthesia Group

Patients undergoing percutaneous nephrolithotomy under spinal anesthesia as part of routine clinical practice. No additional intervention is performed for the purposes of the study.

General Anesthesia Group

Patients undergoing percutaneous nephrolithotomy under general anesthesia as part of routine clinical practice. No additional intervention is performed for the purposes of the study.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients aged 18 years and older who undergo elective percutaneous nephrolithotomy (PCNL) surgery and meet the eligibility criteria. Patients classified as American Society of Anesthesiologists (ASA) physical status I-III are included. All participants receive either spinal or general anesthesia as part of routine clinical practice, and no additional intervention is performed for research purposes.

You may qualify if:

• American Society of Anesthesiologists (ASA) physical status class I-III
• Patients aged 18 years and older

You may not qualify if:

• American Society of Anesthesiologists (ASA) physical status class IV or V
• Patients younger than 18 years
• Active infection or diagnosis of sepsis
• Malignancy
• Chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
• Use of immunosuppressive therapy
• Pregnancy

Sponsors & Collaborators

• Elazıg Fethi Sekin Sehir Hastanesi: lead

Study Sites (1)

Fethi Sekin City Hospital

Elâzığ, Elaziğ, Turkey (Türkiye)

RECRUITING

Central Study Contacts

Sevim ŞENOL KARATAŞ, MD

CONTACT

+905325736611; drsevimkaratas@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist in Anesthesiology and Reanimation

Study Record Dates

• First Submitted: December 24, 2025
• First Posted: January 8, 2026
• Study Start: October 15, 2025
• Primary Completion: April 25, 2026
• Study Completion: April 30, 2026
• Last Updated: April 22, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)