Comparison of Sympathetic Blockade Duration in Brachial Plexus Blocks Performed by Different Methods

NCT07326436 | Completed

• 1 other identifier: Brachial Plexus Block
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective comparative study will evaluate the sympathetic effects of ultrasound-guided infraclavicular versus supraclavicular brachial plexus blocks in adults undergoing upper-extremity surgery. Sympathetic tone will be monitored noninvasively with simultaneous bilateral measurements of perfusion index (pulse-oximetry-derived) and skin temperature obtained at baseline and at predefined post-block intervals until return to baseline. The primary outcome is the duration of sympathetic block. Secondary outcomes are between-approach differences in the time course of perfusion index and skin temperature, and the incidence and magnitude of rebound sympathetic activity.

Conditions

Brachial Plexus Blockade; Sympathetic Blockade; Anesthesia, Conduction

Keywords

supraclavicular brachial plexus block; perfusion index; skin temperature; infraclavicular brachial plexus block; sympathetic blockade

Outcome Measures

Primary Outcomes (1)

• Difference in duration of sympathetic blockade after different US-guided brachial plexus blocks

  Twenty-four hours after nerve blockage

Secondary Outcomes (1)

• Change in perfusion index between infraclavicular and supraclavicular approaches

  Twenty-four hours after nerve blockage

Study Arms (2)

Supraclavicular brachial plexus block

ACTIVE COMPARATOR

Procedure: Supraclavicular brachial plexus block

Infraclavicular brachial plexus block

ACTIVE COMPARATOR

Procedure: Infraclavicular brachial plexus block

Interventions

Infraclavicular brachial plexus block PROCEDURE

A linear US probe (7-13 MHz) will be placed in the infraclavicular area through a lateral sagittal approach, in plane technique will be used and injection will be performed using a 22G 100 mm stimulator needle (Stimuplex A®: B. Braun Melsungen AG, Japan) after antisepsis of the area to be blocked. Intermittent negative aspiration will be performed during all procedures to detect possible vascular puncture. A total of 30 mL of 2% prilocaine containing 0.5% bupivacaine and 5 mcg/mL adrenaline in a 1:1 ratio will be used as local anesthetic.

Infraclavicular brachial plexus block

Supraclavicular brachial plexus block PROCEDURE

A linear US probe (7-13 MHz) will be placed in the supraclavicular area in the coronal oblique plane, in-plane technique will be used, and after antisepsis of the area to be blocked, injection will be performed from lateral to medial direction using a 22G 50 mm stimulator needle (Stimuplex A®: B. Braun Melsungen AG, Japan). Intermittent negative aspiration will be performed during all procedures to detect possible vascular puncture. A total of 30 mL of 2% prilocaine containing 0.5% bupivacaine and 5 mcg/mL adrenaline in a 1:1 ratio will be used as local anesthetic.

Supraclavicular brachial plexus block

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• to 65 year old
• ASA I-II
• Patients scheduled for upper extremity surgery
• Fully oriented and able to cooperate
• Patients who signed the informed consent form and gave consent to participate in the study

You may not qualify if:

• ASA III-IV-V
• Non-cooperation
• Disease that interferes with sensory block assessment
• Known allergy to the medicines to be used
• Pregnant patients
• Coagulopathy or thrombocytopenia
• Patients with anatomical abnormalities or active infection at the points of application

Sponsors & Collaborators

• Bozyaka Training and Research Hospital: lead

Study Sites (1)

Bozyaka Training and Research Hospital

Izmir, İzmir, 35030, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor of medicine

Study Record Dates

• First Submitted: April 10, 2023
• First Posted: January 8, 2026
• Study Start: March 1, 2023
• Primary Completion: September 1, 2023
• Study Completion: September 2, 2023
• Last Updated: January 8, 2026

Record last verified: 2026-01

Locations

TU (1)