Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery

NCT07324863 | Recruiting

• 1 other identifier: 36265MD474/10/25
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.

Conditions

Ultrasound; External Oblique; Rectus Abdominis Plane Block; Neuroendocrine Stress Response; Umbilical Hernia

Outcome Measures

Primary Outcomes (1)

• Neuroendocrine stress response

  Neuroendocrine stress response will be measured by blood glucose level in adults undergoing umbilical hernia repair.

  24 hours postoperatively

Secondary Outcomes (5)

• Serum cortisol level

  24 hours postoperatively

• Time of first rescue analgesia

  24 hours postoperatively

• Total intraoperative fentanyl consumption

  Intraoperatively

• Total morphine consumption

  24 hours postoperatively

• Degree of pain

  24 hours postoperatively

Study Arms (2)

Group I

ACTIVE COMPARATOR

Patients will receive general anesthesia only.

Other: General anesthesia

Group Ⅱ

EXPERIMENTAL

Patients will receive general anesthesia and an external oblique and rectus abdominis plane (EXORA) block with 0.25% bupivacaine.

Other: External oblique and rectus abdominis plane (EXORA) block

Interventions

General anesthesia OTHER

Patients will receive general anesthesia only.

Group I

External oblique and rectus abdominis plane (EXORA) block OTHER

Patients will receive general anesthesia and an external oblique and rectus abdominis plane (EXORA) block with 0.25% bupivacaine.

Group Ⅱ

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged from 21 to 65 years.
• Both sexes.
• American Society of Anesthesiologists (ASA) Physical status I and Ⅱ.
• Schedule for elective umbilical hernia surgery under general anesthesia.

You may not qualify if:

• ASA Ⅲ or Ⅳ.
• Patients with metabolic abnormalities, e.g., diabetes mellitus.
• Patients receiving corticosteroids.
• History of allergies to local anesthetics.
• Bleeding or coagulation disorders.
• Anatomical abnormalities.
• Psychiatric and neurological disorders.
• Complicated hernial defect (obstructed).
• Patient refusal.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, 31527, Egypt

RECRUITING

MeSH Terms

Conditions

Hernia, Umbilical

Interventions

Anesthesia, General; Dental Occlusion

Condition Hierarchy (Ancestors)

Infant, Newborn, Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hernia, Ventral; Hernia, Abdominal; Hernia; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anesthesia; Anesthesia and Analgesia; Dentistry; Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Central Study Contacts

Mayada H Sokeer, Master

CONTACT

00201095315597; mayada.hady@med.tanta.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: December 23, 2025
• First Posted: January 8, 2026
• Study Start: August 1, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: January 8, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)