Ultrasonographic Examination of Other Enthesitis Sites in Patients With Lateral Epicondylitis

NCT07314840 | Recruiting

• 1 other identifier: 09.2025.25-0844
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Lateral epicondylitis (LE) is the tendinopathy of the common extensor tendon. Although exact etiology remains unclear, it is believed to be caused by overuse. Even though, genetics factor related to tendinopathies were defined accompanying tendinopathies in patients with LE is yet to be studied. Madrid sonographic enthesitis index (MASEI) is an ultrasound based scoring system, developed for the evaluation of the enthesitis. Initially developed for ankylosing spondylitis, its usage has also become widespread in other musculoskeletal diseases. The aim of this study is to calculate the MASEI score in patients diagnosed with LE, and compare it to healthy volunteers.

Conditions

Lateral Epicondylitis; Lateral Elbow Tendinopathy (Tennis Elbow)

Keywords

Lateral Epicondylitis; Lateral Elbow Tendinopathy; Tennis Elbow; Enthesitis; Madrid Sonographic Enthesitis Index; MASEI

Outcome Measures

Primary Outcomes (1)

• Madrid Sonographic Enthesitis Index

  Patients will be evaluated with ultrasound at 6 different locations on each side, for total of 12 locations. At each location; structure and thickness of the tendon, the presence of calcifications or enthesophytes, erosions in the bone, regional bursitis, and the presence of power-Doppler signal will be noted. Each parameter has a point of its own. Points obtained from each parameter will be added and total MASEI score (0-136) will be calculated. Higher scores indicate the presence of enthesitis.

  At enrollment

Study Arms (2)

Lateral Epicondylitis

Patients with lateral epicondylitis will be included in this group.

Diagnostic Test: Madrid Sonographic Enthesitis Index

Control

Healthy volunteers with similar demographic characteristics will be enrolled to this group.

Diagnostic Test: Madrid Sonographic Enthesitis Index

Interventions

Madrid Sonographic Enthesitis Index DIAGNOSTIC_TEST

Patients will be evaluated with ultrasound at 6 different locations on each side, for total of 12 locations. These will be insertion points of triceps brachii tendon, quadriceps tendon, proximal and distal patellar tendons, achilles tendon and the plantar fascia. Evaluation parameters are the structure and thickness of the tendon, the presence of calcifications or enthesophytes, erosions in the bone, regional bursitis, and the presence of power-Doppler signal in the entheses.

Also known as: MASEI

Control; Lateral Epicondylitis

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients presented to the outpatient clinic of Physical Medicine and Rehabilitation of Marmara University with elbow pain and diagnosed with lateral epicondylitis will be informed about the study. Willing patients will be enrolled after written consent is taken. Control group will be chosen with volunteers, which have similar demographic characteristics.

You may qualify if:

• Tenderness with palpation at the lateral epicondyle
• Pain aggravated with resisted wrist extension

You may not qualify if:

• History of rheumatologic diseases
• History of elbow, knee or ankle surgery
• History of corticosteroid injections on elbow, knee or ankle
• History of peripheral neuropathy
• Acute trauma

Sponsors & Collaborators

• Marmara University: lead

Study Sites (1)

Marmara University

Istanbul, Maltepe, 34844, Turkey (Türkiye)

RECRUITING

Related Publications (5)

• Ozsoy-Unubol T, Yagci I. Is ultrasonographic enthesitis evaluation helpful for diagnosis of non-radiographic axial spondyloarthritis? Rheumatol Int. 2018 Nov;38(11):2053-2061. doi: 10.1007/s00296-018-4164-4. Epub 2018 Oct 9.

  PMID: 30302556 BACKGROUND

• de Miguel E, Cobo T, Munoz-Fernandez S, Naredo E, Uson J, Acebes JC, Andreu JL, Martin-Mola E. Validity of enthesis ultrasound assessment in spondyloarthropathy. Ann Rheum Dis. 2009 Feb;68(2):169-74. doi: 10.1136/ard.2007.084251. Epub 2008 Apr 7.

  PMID: 18390909 BACKGROUND

• Okur SC, Dogan YP, Mert M, Aksu O, Burnaz O, Caglar NS. Ultrasonographic Evaluation of Lower Extremity Entheseal Sites in Diabetic Patients Using Glasgow Ultrasound Enthesitis Scoring System Score. J Med Ultrasound. 2017 Jul-Sep;25(3):150-156. doi: 10.1016/j.jmu.2017.03.011. Epub 2017 May 6.

  PMID: 30065480 BACKGROUND

• Johns N, Shridhar V. Lateral epicondylitis: Current concepts. Aust J Gen Pract. 2020 Nov;49(11):707-709. doi: 10.31128/AJGP-07-20-5519.

  PMID: 33123709 BACKGROUND

• Karanasios S, Korakakis V, Moutzouri M, Drakonaki E, Koci K, Pantazopoulou V, Tsepis E, Gioftsos G. Diagnostic accuracy of examination tests for lateral elbow tendinopathy (LET) - A systematic review. J Hand Ther. 2022 Oct-Dec;35(4):541-551. doi: 10.1016/j.jht.2021.02.002. Epub 2021 Feb 27.

  PMID: 33814224 BACKGROUND

MeSH Terms

Conditions

Tennis Elbow

Condition Hierarchy (Ancestors)

Elbow Tendinopathy; Tendinopathy; Muscular Diseases; Musculoskeletal Diseases; Elbow Injuries; Arm Injuries; Wounds and Injuries; Tendon Injuries

Study Officials

• İlker Yağcı, Prof. Dr.

  Acıbadem Ataşehir Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Arda Can Kasap, MD

CONTACT

905384590119; drardakasap@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. M.D.

Study Record Dates

• First Submitted: December 18, 2025
• First Posted: January 2, 2026
• Study Start: October 1, 2025
• Primary Completion: January 31, 2026
• Study Completion: January 31, 2026
• Last Updated: January 2, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)