Evaluation of the PERC Score and the YEARS Algorithm in the Diagnosis of Pulmonary Embolism in the Emergency Department

NCT07313501 | Recruiting

• 1 other identifier: 9611
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The current diagnostic strategy for pulmonary embolism relies on clinical evaluation, followed by D-dimer testing and chest CT angiography. However, this approach leads to overuse of CT angiography. Diagnosis remains complex, with nonspecific clinical signs. Recent studies have explored new algorithms, such as the YEARS algorithm and the PERC score, which aim to support the diagnosis and reduce the need for imaging examinations. Their use could decrease waiting times in the emergency department and limit the need for additional investigations.

Conditions

Pulmonary Embolism

Keywords

Pulmonary Embolism; PERC score; D-dimer testing; Chest CT angiography

Outcome Measures

Primary Outcomes (1)

• Number of patients who would not have required imaging if the PERC score and YEARS algorithm criteria had been applied

  Up to 12 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

\- Adult patient (≥18 years) admitted to the adult emergency department of the Strasbourg University Hospital over a 6-month period (January to June 2024), for whom a D-dimer test and chest imaging (thoracic CT angiography or ventilation/perfusion scintigraphy) were performed

You may qualify if:

• Adult patient (≥18 years)
• Patient admitted to the adult emergency department of the Strasbourg University Hospital over a 6-month period (January to June 2024), for whom a D-dimer test and chest imaging (thoracic CT angiography or ventilation/perfusion scintigraphy) were performed

You may not qualify if:

• \- No D-dimer test or test performed for another indication, no chest imaging (CT angiography or scintigraphy), long-term anticoagulant treatment.

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service d'Urgences Médico-Chirurgicales Adules - CHU de Strasbourg - France

Strasbourg, 67091, France

RECRUITING

MeSH Terms

Conditions

Pulmonary Embolism

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

François WEILL, MD

CONTACT

33 3.88.11.54.67; francois.weill@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 17, 2025
• First Posted: January 2, 2026
• Study Start: February 26, 2025
• Primary Completion: February 1, 2026
• Study Completion: February 1, 2026
• Last Updated: January 2, 2026

Record last verified: 2025-12

Locations

FR (1)