Assessment of Contrast Enhancement Boost for the Direct Identification of Pulmonary Emboli in Thoracic CT Angiography

NCT04654156 | Completed

• 1 other identifier: 2020PI216
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Pulmonary embolism is a common cardiovascular disease and thoracic CT angiography is currently considered the gold standard for its non-invasive diagnosis. However, the diagnostic performance of CT angiography can be hampered by an insufficient enhancement of pulmonary arteries. Contrast Enhancement Boost (CE Boost) is a post-processing technique using an iodine density map to artificially improve pulmonary artery enhancement. This retrospective study compares standard CT-angiography images with CE Boost images to assess the potential improvement of diagnostic performance for the detection of pulmonary embolism.

Conditions

Pulmonary Embolism

Keywords

Pulmonary embolism

Outcome Measures

Primary Outcomes (1)

• Number of thrombi within each branch of the pulmonary arteries

  The pulmonary arteries were divided into 11 zones according to their anatomical characteristics then each visible thrombus was reported in a Excel table according to the zone where it was located

  Between March and June 2018

Study Arms (2)

Pathological group

Patients with pulmonary embolism on thoracic CT angiography

Diagnostic Test: Contrast Boost post processing technique

Healthy group

Patients without pulmonary embolism on thoracic CT angiography

Diagnostic Test: Contrast Boost post processing technique

Interventions

Contrast Boost post processing technique DIAGNOSTIC_TEST

Contrast Enhancement Boost is a post-processing technique that uses an iodine density map generated by subtracting a pre- and post-contrast CT acquisition to artificially enhance pulmonary artery enhancement.

Healthy group; Pathological group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patient referred in our institution by emergency practitioners who underwent thoracic CT angiography for clinical suspicion of pulmonary embolism between March and June 2018

You may qualify if:

• Patient who underwent thoracic CT angiography for suspicion of pulmonary embolism in our institution between March and June 2018

You may not qualify if:

• None

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

CHRU Nancy

Nancy, Meurthe-et-Moselle, 54000, France

Location

MeSH Terms

Conditions

Pulmonary Embolism

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 6, 2020
• First Posted: December 4, 2020
• Study Start: January 1, 2019
• Primary Completion: January 1, 2019
• Study Completion: January 1, 2019
• Last Updated: December 4, 2020

Record last verified: 2020-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)