Multilevel Determinants of Socioeconomic Disparities in Geographic Late-Stage Hepatocellular Carcinoma Hotspots

NCT07312162 | Recruiting DMC

• 4 other identifiers: 19PS-21-7NCI-2024-03737K23MD016963P30CA014089
• Study Type: observational
• Target: 730
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates barriers to early detection of liver cancer.

Conditions

Hepatocellular Carcinoma

Outcome Measures

Primary Outcomes (2)

• Social determinants of health

  Patient social determinants of health-related needs will be measured through a health questionnaire created for the study. The patient can respond yes or no to having a lack of transportation to and from appointments. The patient is given a scale of never true, sometimes true and often true for questions regarding food insecurity. The patient can indicate that they do or do not have housing today (or choose not to answer), and they can indicate how many times they moved in the last year as 0, 1, or 2+. For the remaining questions regarding housing, paying for utilities, paying for medications, unemployment, education and child or family care, the patient can respond yes, no or choose not to answer. Responses of yes indicate the patient has a need, and no indicates that they do not have a need.

  Up to 4 years

• Barriers to completion of the early detection pathway for liver cancer

  For assessment we will conduct semi-structured interviews with key stakeholders, including low-income patients with liver cancer, providers in an interconnected safety net system, and community leaders of hotspot neighborhoods.

  Up to 4 years

Study Arms (1)

Observational

Participants complete surveys, have their medical records reviewed, and may complete an interview on study.

Other: Non-Interventional Study

Interventions

Non-Interventional Study OTHER

Non-interventional study

Observational

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients (18+ years of age) of all stages with a diagnosis of HCC defined by guideline-based radiographic findings on cross-sectional imaging and/or histopathology

You may qualify if:

• \* Adults (18+)
• New diagnosis of HCC
• Able to provide informed consent
• Additional criteria:
• Must complete survey
• Residential address in a late stage hotspot
• Medicaid insurance or uninsured
• English, Spanish and Chinese speakers

You may not qualify if:

• \* Residence outside of Los Angeles County
• Non-HCC liver tumors
• Incarcerated patients
• Pregnant women

Sponsors & Collaborators

• National Institute on Minority Health and Health Disparities (NIMHD): collaborator
• National Cancer Institute (NCI): collaborator
• University of Southern California: lead

Study Sites (1)

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

RECRUITING

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Study Officials

• Kali Zhou

  University of Southern California

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Kali Zhou

CONTACT

323-865-0451; kalizhou@usc.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 20, 2024
• First Posted: December 31, 2025
• Study Start: January 1, 2022
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2027
• Last Updated: January 30, 2026

Record last verified: 2026-01

Locations

US (1)