Trials Sponsors Conditions Drugs Pricing

Conditions

Corneal Ulcer (Diagnosis)Keratitis Bacterial

Outcome Measures

Primary Outcomes (1)

Best Corrected Visual Acuity (BCVA)
BCVA (logMAR) at 3 months post-randomization in the study eye.
From enrollment to 3 months

Secondary Outcomes (4)

Visual Improvement
From enrollment (Day 1) to Week 1, Month 1, Month 3.
Time to re-epithelialization
From enrollment to 3 months
Intraocular Pressure (IOP)
From enrollment (Day 1) to Day 3, 1 Week, 1 Month, 3 Months.
Complications
From enrollment to Month 3.

Study Arms (2)

Intervention Arm

EXPERIMENTAL

Standard Topical Antibiotic Therapy + Fluorometholone

Drug: Adjunctive Topical Fluorometholone (FML) 0.1%Drug: Standard Topical Antibiotic Therapy

Control Arm

ACTIVE COMPARATOR

Standard Topical Antibiotic Therapy Alone

Drug: Standard Topical Antibiotic Therapy

Interventions

Adjunctive Topical Fluorometholone (FML) 0.1%Drug

Adjunctive Topical Fluorometholone (FML) 0.1% will be used

Intervention Arm

Standard Topical Antibiotic TherapyDrug

Patients will be treated with antibiotics (Cefazolin, Tobramycin or Moxifloxacin) we per treating physician

Control Arm

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Adults aged ≥ 18 years.
Clinical diagnosis of a bacterial corneal ulcer based on slit-lamp examination.

Sponsors & Collaborators

Vishal Jhanji
Otherlead
University of Pittsburgh Medical Center
Othercollaborator

Study Sites (1)

UPMC Vision Institute

Pittsburgh, Pennsylvania, 15219, United States

Rose Carla Aubourg, BACONTACT412-642-7888 aubourgrc@upmc.edu

Sarah WatersCONTACT412-642-7888 waterssa2@upmc.edu

Vishal Jhanji, MDPRINCIPAL INVESTIGATOR

Alex Mammen, MDSUB INVESTIGATOR

Sabrina Mukhtar, MDSUB INVESTIGATOR

Prakash Gaurav, MDSUB INVESTIGATOR

MeSH Terms

Conditions

Corneal UlcerDisease

Interventions

Fluorometholone

Condition Hierarchy (Ancestors)

Eye InfectionsInfectionsKeratitisCorneal DiseasesEye DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

PregnadienediolsPregnadienesPregnanes

Study Officials

Vishal Jhanji, MD
University of Pittsburgh
PRINCIPAL INVESTIGATOR

Central Study Contacts

Rose Carla Aubourg, BA

CONTACT

412-642-7888 aubourgrc@upmc.edu

Sarah Waters

CONTACT

412-642-7888

Study Design

Study Type: interventional
Phase: phase 2
Allocation: RANDOMIZED
Masking: NONE
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: SPONSOR INVESTIGATOR
PI Title: Professor of Ophthalmology

Study Record Dates

First Submitted

December 26, 2025

First Posted

December 30, 2025

Study Start

October 31, 2026

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Fluorometholone Study

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (2)

Intervention Arm

Control Arm

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (2)

Intervention Arm

Control Arm

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations